Ketamine和Bicucullin对帕金森模型的影响  

INFLUENCE OF KETAMINE AND BICUCULLIN ON MICE WITH THE PARKINSON'S DISEASE

作　　者：仲伟法[1] 王彦英[2] 

机构地区：[1]济宁医学院 [2]济宁医学院附属医院

出　　处：《济宁医学院学报》2001年第3期19-21,共3页Journal of Jining Medical University

摘　　要：目的　为帕金森氏病的发病机理及兴奋性氨基酸受体拮抗剂对帕金森氏病的防治提供理论根据。方法　本实验采用MPTP腹腔注射建立C57BL小黑鼠帕金森氏病模型的过程中 ,同时用兴奋性氨基酸NMDA受体拮抗剂Ketamine和GABA受体拮抗剂Bicucullin ,观察其帕金森行为症状、病理变化及生化改变。结果　Ketamine加MPTP组和Bicucullin加MPTP组及MPTP组和生理盐水组比较 ,上述指标都有明显改变。结论　NMDA受体拮抗剂对小鼠帕金森氏病模型具有防治作用 ,GABA神经元的功能降低可加重帕金森氏病的症状。Objective To seek the pathological mechanism of the parkinsons disease,and to find the pathological basis of EAA-receptor antagonis on the disease.Methods The C 57 BL mice with the Parkinsons disease,which were reproduced by ip injection of MPTP,were administered with ketamine,a NMDA-receptor antagonist,or Bicucullin,a GABA-receptor antagonist,and their behavioral,pathological and biochemical changes were carefully observed and analyzed.Results Compared with the control group,the remarkable changes in those aforementioned indexes were observed in groups of Ketamine+MPTP,Bicucullin+MPTP,and MPTP.Conclusion The decreased function of central GABA nerves aggravated the symptoms of the Parkinsons disease and NMDA-receptor antagonists might have a therapeutic effect on the disease.

关 键 词：帕金森氏病 MPTP NMDA受体 多巴胺 四氢吡啶 KETAMINE Bicucullin 

分 类 号：R742.5[医药卫生—神经病学与精神病学]