阿尔茨海默病患者血浆脱氢表雄酮水平的研究  

Serum dehydroepiandrosterone of Alzheimer's disease

作　　者：刘中霖[1] 邢诒刚[1] 陶恩祥[1] 刘军[1] 吕瑞妍[1] 肖颂华[1] 

机构地区：[1]中山医科大学孙逸仙纪念医院神经科,广州市510120

出　　处：《实用老年医学》2001年第5期241-242,共2页Practical Geriatrics

摘　　要：目的　探讨阿尔茨海默病患者血浆脱氢表雄酮 (DHEA)水平的变化。　 方法　采用放射免疫法测定 48例阿尔茨海默病患者血浆DHEA的水平 ,并与 44例正常老年人 (对照组 )进行比较。　 结果　阿尔茨海默病患者血浆DHEA的平均水平是 ( 3 342± 1 438)ng·ml-1,而对照组为 ( 6 6 6 4± 1 6 2 4)ng·ml-1,2组间比较有显著性差异 (P <0 0 5 )。　 结论 　阿尔茨海默病的发生可能与其血浆DHEA水平的下降有关 ,DHEA可作为阿尔茨海默病的一项诊断指标。Objective To investigate the serum dehydroepiandrosterone level in Alzheimers disease. Methods The concentration of dehydroepiandrosterone was detected using radioimmunoassay in 48 AD patients and 44 healthy control subjects. Results The concentration of dehydroepiandrosterone in AD was(3 342±1 438)ng·ml -1 ,while it was(6 664±1 624)ng·ml -1 in normal subjects.There was significant difference between the two groups. Conclusions Our results indicated that there might be correlation between AD and the decrease of dehydroepiandrosterone.DHEA may be a clinical marker in the diagnosis of AD.

关 键 词：阿尔茨海默病 脱氢表雄酮 放射免疫法 AD发病机制 

分 类 号：R749.16[医药卫生—神经病学与精神病学] Q579.11[医药卫生—临床医学]