番茄红素对甲基戊基亚硝胺在大鼠中致癌性的影响  

EFFECT OF LYCOPENE ON CARCINOGENICITY OF N METHYL N AMYLNITROSAMINE IN WISTAR RATS

作　　者：张庆英[1] 黄革 罗家逸 沈忠英[2] 林昆 沈健[2] 

机构地区：[1]汕头大学医学院卫生学教研室,广东汕头515031 [2]汕头大学医学院病理教研室,广东汕头515031

出　　处：《癌变．畸变．突变》2001年第3期151-154,共4页Carcinogenesis,Teratogenesis & Mutagenesis

基　　金：广东省医药卫生青年科学研究基金资助!(B2 0 0 0 0 94)

摘　　要：目的 :观察番茄红素对甲基戊基亚硝胺 (MANA)致癌性的影响。方法 :随机将Wistar大鼠分为 3组 :MANA组 (M )、MAN A +番茄酱组 (M +LP)和对照组 (C)。实验期为 2 6周 ,观察大鼠食管和胃粘膜病理变化 ,同时检测血清活性氧单位 (ROSu nit)、超氧化物歧化酶 (SOD)、丙二醛 (MDA)以及全血谷胱甘肽过氧化物酶 (GSH Px)水平。结果 :M组和M +LP组大鼠食管和前胃均发生癌前病变 ,而M +LP组大鼠癌前病变发生率低于M组 ;M +LP组大鼠血中ROSunit、SOD、GSH Px活性较M组高 ,MDA含量较M组低。结论 :番茄红素具有抑制MANA致癌的作用 。Purpose: To study the effects of lycopene on the carcinogenicity of N methyl N amylnitrosamine(MANA) in Wistar rats. Methods: The rats were randomly divided into three groups: simple MANA (M), MANA plus tomato jam (M+LP) and control(C) groups. The experiment lasted 26 weeks. Histological \{examination\} was done and the levels of ROS unit, SOD, GSH Px and MDA in the blood were determined. Results: There were precancerous lesions of esophagus or forestomach in the M and M+LP groups. The incidence of precancerous lesions in the M+LP group was decreased, and the levels of ROS unit, SOD, GSH Px in the blood were higher, but the content of MDA was decreased. Conclusion: Lycopene may have an inhibitory effect on the carcinogenicity of MANA. The effect may be due to the inhibition of lipid peroxidation.

关 键 词：亚硝胺 食管癌 番茄红素 

分 类 号：R735.1[医药卫生—肿瘤]