植酸和魔芋干预二甲肼诱发ICR小鼠大肠癌的初步研究  

Preliminary study of phytic acid and konjac mannan interfering the dimethylhydrazine-indticing Colorectal careinoma in ICR mice

作　　者：李国熊[1] 李英[2] 

机构地区：[1]杭州市第一医院内科 [2]浙江医科大学生化教研室

出　　处：《实用肿瘤杂志》1991年第3期165-168,共4页Journal of Practical Oncology

摘　　要：饮食与大肠癌的关系极为密切,植酸(PA)和魔芋(KM)均为天然食物。本实验表明在二甲肼诱发ICR 小鼠大肠癌过程中,2%PA 饮水25周能使肿瘤发生率和浸润性生长发生率分别从100.0%和70.0%下降至42.9%14.3%;5～10%KM 饲料喂饲25周能使肿瘤发生率从100.0%下降至50.0%,但未能观察到 PA 和 KM协同抑癌作用。PA 和 KM 也能显著地减轻与肿瘤密切有关的超氧化物歧化酶、丙二醛等生化指标的变化程度。Colorectal carcinoma is closely related to diets.Phytic acid(PA)and konjac mannan(KM) are both natural diets.Our experiment results showed that having been given 2% PA drinking water for 25 weeks,the incidence of tumor and infiltrating rate could be reduced from 100.0% and 70.0% to 42.9% and 14.3% respectively during the dimethylhydrazine carcinogenesis of colo- rectal in ICR mice.At the same time,the tumor incidence could also be reduced from 100.0% to 50.0% by feeding 5～10% KM diet for 25 weeks.But no synergism of inhibition between PA and KM could be observed.Testing tumor closely related to biochemical markers,e.g.supcroxide dismutase and malonyl dialdehyde,it has also been found that PA and KM could significantly reduce their change ranges.

关 键 词：大肠肿瘤 植酸 魔芋 二甲肼 

分 类 号：R73－36[医药卫生—肿瘤]