肝癌门静脉癌栓的分次立体定向三维适形放射治疗  

Fractlionated Stereotatlic 3D conformal Radiotherapy of Tumor Thrombus in Portal Vein

作　　者：齐立伟[1] 袁亚文[1] 苏勋林[1] 王庆夕[1] 

机构地区：[1]连云港市第一人民医院放疗科,连云港222002

出　　处：《海南医学》2002年第3期21-23,共3页Hainan Medical Journal

摘　　要：目的　初步探讨分次立体定向三维适形放射治疗肝癌伴门静脉癌栓患者的近期疗效。方法　 3 1例肝癌伴门静脉癌栓患者应用中科院大恒公司适形系列及 3D治疗计划系统。 10MV -X射线总剂量DT40～ 48GY ,1～ 2个中心 ,70 %～ 90 %等剂量曲线包绕肿瘤边缘。分割方式 :68GY 次 ,3次 周。结果　临床症状改善为 10 0 % ;影像学有效率为 85 .7% ;总生物剂量相同时 ,6GY和 8GY组疗效无差别 ;18例门静脉癌栓全消 ,7例大部分消退 ,3例癌栓略缩小 ,所有患者临床症状得以改善 ,生存期延长。结论　分次立体定向三维适形放射治疗肝癌伴门静脉癌栓患者近期疗效肯定 。Objectives:Short-term results of fractionated stereotatic 3D conformal radiotherapy for tumor thrombus in portal vein at the primary focus.Methods:From Aug 11,1999 to Sep 12,2000,31 patients tumor thrombus in portal vein were treated by with 10 MV photons.The total does was 40 48gy on the 70%-90% isodose curres normalized to isocenter by multifractions of fraction size 6.0～8.0gy,with interfraction duration of one day,one-two isoceters.Results:Clinical symptom improve 100%,image valid 85.7%,curative effeet is not difference of 6GY and 8GY when living thing doses cqual;The thrombus disappeared eighteen cases,the mass of tumor thrombus decreased is seven cases,the less of tumor thrombus decreased in three cases,The survival time in the group with treatment was longer than in that the control group.Conclusions:fractionated stereotatic 3D conformal radiotherqpy is strongly indicated for tumor thrombus in portal vein at the primary focus apply in clinical.

关 键 词：门静脉癌栓 立体定向 三维适形放射治疗 肝癌 

分 类 号：R735.7[医药卫生—肿瘤]