SUMOylation of Fragile X Mental Retardation Protein: A Critical Mechanism of FMRP-Mediated Neuronal Function  

作　　者：Mingzhu Tang Liqun Lu Feng Xie Linxi Chen 

机构地区：[1]Institute of Pharmacy and Pharmacology, Learning Key Laboratory for Pharmacoproteomics, Hunan Province Cooperative Innovation Center for Molecular Target New Drug Study, University of South China

出　　处：《Neuroscience Bulletin》2018年第6期1100-1102,共3页神经科学通报（英文版）

基　　金：supported by the National Natural Science Foundation of China (81503074)

摘　　要：Recently, Khayachi et al.;showed that fragile X mental retardation protein （FMRP） is an active substrate of the small ubiquitin-like modifier （SUMO） pathway in neurons.FMRP SUMOylation is induced by the activation of metabotropic glutamate receptors （mGlu5Rs）. FMRP

关 键 词：FXS AD In SUMOylation of Fragile X Mental Retardation Protein 

分 类 号：R[医药卫生]