Effectiveness of Traditional Chinese Medicine on chemo-radiotherapy induced leukaemia in patients with lung cancer:a Meta-analysis  

作　　者：Li Yu Xiong Chan Qin Erqi Li Lin Zhuang Guangtong Yu Zheng 

机构地区：[1]Respiratary Department of Pi Du District Hopspital of Traditional Chinese Medicine,Chengdu 611730,China [2]Research Department of Pi Du District Hopspital of Traditional Chinese Medicine,Chengdu 611730,China [3]Cardiovascular Department of Pi Du District Hopspital of Traditional Chinese Medicine,Chengdu 611730,China

出　　处：《Journal of Traditional Chinese Medicine》2018年第5期661-667,共7页中医杂志（英文版）

基　　金：Supported by Science Projects of Administration of Traditional Chinese Medicine of Sichuan(No.2016C067)

摘　　要：OBJECTIVE: To assess the curative effect of Traditional Chinese Medicine(TCM) on leukopenia induced by chemo-radiotherapy in patients with lung cancer.METHODS: A comprehensive electronic search in Medline, Embase, the Cochrane Libary database,China National Knowledge Infrastructure Database(CNKI) and Wanfang Database was conducted up to July 2017. Random-effects model was used to estimate the standardized mean differences(SMDs)with 95% confidence intervals(CIs). Eleven studies with a total of 957 patients were included in this meta-analysis.RESULTS: The effectiveness in TCM group was higher than control group [RR = 1.60, 95% CI(1.38, 1.85),P < 0.000 01]. Compare with Western Medicinegroup, the effectiveness has no significant difference [RR = 0.96, 95% CI(0.82, 1.12), P = 0.57]. The ineffective rate in test group was lower than the control group [RR = 0.30, 95% CI(0.21, 0.42), P < 0.00001].CONCLUSION: By meta-regression it was suggested that TCM has curative effect on leukopenia induced by chemo-radiotherapy in patients with lung cancer, but by the influence of number and quality of researches, publication bias, more evidence from high quality studies, and larger cohorts for observational trials are needed.OBJECTIVE: To assess the curative effect of Traditional Chinese Medicine(TCM) on leukopenia induced by chemo-radiotherapy in patients with lung cancer.METHODS: A comprehensive electronic search in Medline, Embase, the Cochrane Libary database,China National Knowledge Infrastructure Database(CNKI) and Wanfang Database was conducted up to July 2017. Random-effects model was used to estimate the standardized mean differences(SMDs)with 95% confidence intervals(CIs). Eleven studies with a total of 957 patients were included in this meta-analysis.RESULTS: The effectiveness in TCM group was higher than control group [RR = 1.60, 95% CI(1.38, 1.85),P < 0.000 01]. Compare with Western Medicinegroup, the effectiveness has no significant difference [RR = 0.96, 95% CI(0.82, 1.12), P = 0.57]. The ineffective rate in test group was lower than the control group [RR = 0.30, 95% CI(0.21, 0.42), P < 0.00001].CONCLUSION: By meta-regression it was suggested that TCM has curative effect on leukopenia induced by chemo-radiotherapy in patients with lung cancer, but by the influence of number and quality of researches, publication bias, more evidence from high quality studies, and larger cohorts for observational trials are needed.

关 键 词：Traditional Chinese Medicine Lung cancer ADENOCARCINOMA SQUAMOUS carcinoma LEUKOPENIA Meta Analysis 

分 类 号：R[医药卫生]