伊托必利致锥体外系症状  

Extrapyramidal symptoms caused by itopride

作　　者：柯巍[1] 刘敏[1] 李月阳[1] 王相峰 Ke Wei;Liu Min;Li Yueyang;Wang Xiangfeng(Department of Pharmacy, the First Hospital of Jilin University, Changchun 130021, China)

机构地区：[1]吉林大学第一医院药学部,长春130021

出　　处：《药物不良反应杂志》2018年第6期474-475,共2页Adverse Drug Reactions Journal

摘　　要：1例82岁女性患者因不稳定型心绞痛、冠状动脉粥样硬化性心脏病、胃食管反流症给予单硝酸异山梨酯缓释胶囊50mg口服、1次/d,丹参多酚酸盐200mg溶入5%葡萄糖注射液250ml静脉滴注、1次/d,盐酸伊托必利片50mg口服、3次/d,复方消化酶胶囊(Ⅱ)1粒口服、3次/d。用药第3天,患者突然出现大汗、发热(体温39℃)伴四肢粗大震颤和双上肢意向性震颤。急查血常规,未见明显异常。考虑为盐酸伊托必利片所致锥体外系症状。停用该药,给予地西泮10mg静脉注射,并进行物理降温、精神安慰等处理。约2h后患者体温恢复正常,约8h后震颤消失。其他药物继续应用,患者未再出现类似症状。An 82-year-old female patient received oral isosorbide mononitrate sustaind-release capsules 50 mg once daily,an IV infusion of Danshen Duofensuan Yan(丹参多酚酸盐)200 mg dissolved in 5% glucose injection 250 ml once daily,oral itopride 50 mg thrice daily,and oral compound digestive enzyme capsules(Ⅱ)1 pill thrice daily for unstable angina,coronary atherosclerotic heart disease,and gastroesophageal reflux(GER).On day 3 of treatments,the patient suddenly presented with sweating,fever(39 ℃),accompanied by coarse tremor in limbs and intention tremor in both upper limbs.Blood routine test showed no obvious abnormality.It was considered that itopride induced the extrapyramidal symptoms.Itopril was withdrawn and an IV injection of diazepam 10 mg,physical cooling,and mental comfort were given.About 2 hours later,the patient's temperature returned to normal and about 8 hours later,the tremor disappeared.Other drugs were continued to use and no similar symptoms recurred.

关 键 词：苯甲酰胺类 震颤 锥体外系症状 伊托必利 

分 类 号：R969.3[医药卫生—药理学]