Management Recommendations on Sleep Disturbance o Patients with Parkinson's Disease  

作　　者：Chun-Feng Liu Tao Wang Shu-Qin Zhan De-Qin Geng Jian Wang Jun Liu Hui-Fang Shang Li-Juan Wang Piu Chan Hai-Bo Chen Sheng-Di Chen Yu-Ping Wang Zhong-Xin Zhao K Ray Chaudhuri 

机构地区：[1]Department of Neurology,The Second Affiliated Hospital of Soochow University,Suzhou,Jiangsu 215004,China [10]Department of Neurology,Beijing Hospital,National Center of Gerontology,Beijing 100730,China [11]Departmentof Neurology,Changzheng Hospital,Second Military Medical University,Shanghai 200003,China [12]National Parkinson Foundation Centre of Excellence and The Maurice Wohl Clinical Neuroscience Institute,King's College London and King's College Hospital, London WC2R 2LS.UK [2]Institute of Neuroscience,Soochow University,Suzhou,Jiangsu 215004,China [3]Department of Neurology,Union Hospital,Tongji Medical College,Huazhong University of Science and Technology,Wuhan,Hubei 430022,China [4]Department of Neurology,Xuan Wu Hospital,Capital Medical University,Beijing 100053,China [5]Department of Neurology,Affiliated Hospital of Xuzhou Medical University,Xuzhou,Jiangsu 221006,China [6]Department of Neurology and National Clinical Research Center for Aging and Medicine,Huashan Hospital,Fudan University,Shanghai 200040,China [7]Department of Neurology and Institute of Neurology,Ruijin Hospital Affiliated to Shanghai JiaoTong University School of Medicine,Shanghai 200025,China [8]Department of Neurology,West China Hospital,Sichuan University,Chengdu,Sichuan 610041,China [9]Department of Neurology,Guangdong Neuroscience Institute,Guangdong General Hospital,Guangdong Academy of Medical Sciences,Guangzhou, Guangdong 510080,China

出　　处：《Chinese Medical Journal》2018年第24期2976-2985,共10页中华医学杂志（英文版）

摘　　要：INTRODUCTION Sleep disturbance is one of the most common nonmotor symptoms in Parkinson's disease (PD).Sleep disturbance affects 40-98% of PD patients in the world. In China, the prevalence of PD patients with sleep disturbance ranges from 47.66% to 89.10%. Sleep disturbance usually has adverse impact on the quality of life of PD patients. Apossible pathogenesis of PD with sleep disturbance include thalamocortical pathway degeneration and changes of neurotransmitter systems. The etiology of sleep disturbance is multifactorial,involving degeneration of areas regulating sleep,sleep structure affected by drugs,sleep disturbance induced by drug,and sleep fragmentation by multiple factors.

关 键 词：EXCESSIVE DAYTIME SLEEPINESS INSOMNIA Parkinson's Disease Rapid Eye Movement SLEEP Behavior Disorder SLEEP Disturbance 

分 类 号：R[医药卫生]