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Ursolic acid inhibiting excessive reticulophagic flux contributes to alleviate ochratoxin A-induced endoplasmic reticulum stress-and mitochondrial-mediated apoptosis
《Food Science and Human Wellness》2025年第4期1318-1329,共12页Huiqiong Deng Wenying Chen Lingyun Han Boyang Zhang Xun Luo Song Yao Hongwei Wang Yao Zhou Shuangchao Liu Xiao Li Shen 
financially supported by the National Natural Science Foundation of China(82060598,32260587);the Natural Science Foundation of Guizhou Province(QKH-J-ZK[2021]181);the Scientific Research Program of Guizhou Provincial Department of Education(QJJ[2023]019);the Science&Technology Program of Guizhou Province(QKHPTRC-CXTD[2022]014);the Excellent Youth Talents of Zunyi Medical University(17zy-006);the Innovation and Entrepreneurship Training Program for College Students of Guizhou Province(S202210661138);the Innovation and Entrepreneurship Training Program for College Students of Zunyi Medical University(ZYDC2021108)。
Foods and animal feeds frequently become contaminated with the nephrotoxic ochratoxin A(OTA).Our prior research has indicated that ursolic acid(UA),which is widely present in fruits and medicinal plants,has the potent...
关键词：Ochratoxin A Ursolic acid Endoplasmic reticulum(ER)stress ER-phagy ER-phagic flux Apoptosis 
USP18 Antagonizes Pyroptosis by Facilitating Selective Autophagic Degradation of Gasdermin D
《Research》2025年第1期149-163,共15页Liqiu Wang Mengqiu Li Guangyu Lian Shuai Yang Yaoxing Wu Jun Cui 
supported by the National Natural Science Foundation of China(32300730);the Guangdong Science and Technology Department(2023B12120600280);the National Postdoctoral Program for Innovative Talents of China(BX20220365);the China Postdoctoral Science Foundation(2023M734057);the Fundamental Research Funds for the Central Universities(23yxqntd001).
As a key executioner of pyroptosis,Gasdermin D(GSDMD)plays a crucial role in host defense and emerges as an essential therapeutic target in the treatment of inflammatory diseases.So far,the understanding of the mechan...
关键词：USP excessive innate immun host defense innate immune responses ubiquitin specific peptidase selective autophagy 
Exploration of electrosensitization of Sifeng(EX-UE10)in children with constipation(syndrome of excessive heat in intestine)based on meridian detection
《Journal of Acupuncture and Tuina Science》2025年第1期101-106,共6页LI Mengtian ZHAO Keqin LIU Jing JING Fujie 
山东省自然科学基金项目,No.ZR2021MH299。
Objective:To observe the electrosensitization of Sifeng(EX-UE10)in children with constipation due to excessive heat in intestine.Methods:The meridian values of Sifeng(EX-UE10)in 80 children with constipation due to ex...
关键词：Meridian Point Detection Point Sifeng(EX-UE10) Points Extraordinary Specificity of Points CONSTIPATION Syndrome of Excessive Heat in Intestine Child Preschool 
Fluid-solid coupling numerical simulation of micro-disturbance grouting treatment for excessive deformation of shield tunnel
《Underground Space》2024年第6期87-100,共14页Yanjie Zhang Zheng Cao Chun Liu Hongwei Huang 
supported by the Natural Science Foundation of Henan,China(Grant No.242300421646);the Key Laboratory of Geotechnical and Underground Engineering of Ministry of Education,Tongji University,China(Grant No.KLE-TJGE-B2205).
Micro-disturbance grouting is a recovery technique to reduce the excessive deformation of operational shield tunnels in urban areas.The grout mass behaves as a fluid in the ground before hardening to form a grout–soi...
关键词：Fluid-solid coupling Discrete element method Pore density flow Micro-disturbance grouting Soil-tunnel interaction 
Emergence of antibiotic resistance due to the excessive use of antibiotics in medicines and feed additives:A global scenario with emphasis on the Indian perspective
《Emerging Contaminants》2024年第4期363-380,共18页Mithuna R Tharanyalakshmi R Ishan Jain Shivangi Singhal Divyanshu Sikarwar Sovik Das JRanjitha Devanita Ghosh Mohammad Mahmudur Rahman e Bhaskar Das 
Antibiotics were discovered for medicinal applications,notably in the last century and since then,they have been prevalently employed for prophylactic purposes in various sectors in the last few decades.Due to the non...
关键词：Antibiotic remediation Antibiotic residues Antibiotics resistance Feed antibiotics Growth promoters 
Activation of the PGC-1α-mediated mitochondrial glutamine metabolism pathway attenuates female offspring osteoarthritis induced by prenatal excessive prednisone
《Science China(Life Sciences)》2024年第11期2382-2397,共16页Qingxian Li Fan Zhang Yongguo Dai Liang Liu Liaobin Chen Hui Wang 
supported by the National Key Research and Development Program of China(2020YFA0803900);the National Natural Science Foundation of China(81972036,U22A20362,82030111);Hubei Province’s Outstanding Medical Academic Leader Program(2019);China Postdoctoral Science Foundation(2023M742931).
Osteoarthritis is a chronic,age-related joint disease.Previous studies have shown that osteoarthritis develops during intrauterine development.Prednisone is frequently used to treat pregnancies complicated by autoimmu...
关键词：cartilage development glutamine metabolism mitochondrial biogenesis prenatal prednisone exposure fetal-originated osteoarthritis 
Single-dose methamphetamine administration impairs ORM retrieval in mice via excessive DA-mediated inhibition of PrL^(Glu)activity
《Acta Pharmacologica Sinica》2024年第11期2253-2266,共14页Jian-chi Ma Xiao-hang Che Xiao-na Zhu Ao-xin Ren Yue Hu Cheng-li Yang Zhong-tian Xu Yu-ting Li Chun-fu Wu Jing-yu Yang 
supported by the National Natural Science Foundation of China(82273916,JYY);the National Natural Science Foundation of China Youth Fund Project(82204373,XHC);and the Youth Scientific Research Project of the Educational Commission of Liaoning Province(JYTQN2023320,XHC).
Methamphetamine(METH),an abused psychostimulant,impairs cognition through prolonged or even single-dose exposure,but animal experiments have shown contradictory effects on memory deficits.In this study we investigated...
关键词：cognitive deficits METHAMPHETAMINE object recognition memory memory retrieval impairment prelimbic cortex D2 receptors 
A Discussion on the Issue of Excessive Academic Burden among Middle School Students
《Journal of Contemporary Educational Research》2024年第11期6-15,共10页Pinghui Tu 
2023 Project of the National Office of Science Planning Project Management“Research on Effective Measures to Reduce the Heavy Workload of Middle School Students”(23BXJ32640)。
At present,the heavy academic workload of middle school students is a common problem,which is still questioned by parents,concerned by the government,and hotly debated by society.This paper summarizes the following ei...
关键词：Middle school students Excessive academic burden DISCUSSION 
Excessive ER-phagy mediated by FAM134B contributes to trophoblast cell mitochondrial dysfunction in preeclampsia
《Acta Biochimica et Biophysica Sinica》2024年第10期1446-1459,共14页Andi Wang Zhuo Li Dan Zhang Chang Chen Hua Zhang 
supported by the grants from the National Natural Science Foundation of China(Nos.81971406 and 82271715);the 111 Project[No.Yuwaizhuan(2016)32];the Chongqing Science&Technology Commission(No.cstc2021jcyj-msxmX0213);the Natural Science Foundation of Chongqing,China(No.CSTB2022N SCQ-MSX1679);the Chongqing Municipal Education Commission(No.KJZD-K202100407);the Chongqing Health Commission and Chongqing Science&Technology Commission(No.2021MSX M121).
Autophagy dysregulation and Ca2+-induced mitochondrial dysfunction in trophoblast cells are proposed to contribute to preeclampsia(PE)development.FAM134B is identified as a receptor associated with endoplasmic reticul...
关键词：PREECLAMPSIA endoplasmic reticulum autophagy(ER-phagy) mitochondria-associated endoplasmic reticulum membrane mitochondrial dysfunction lipidomic metabolome 
Reconstruction of Gold Surface with Excessive Sulfur Source During Transition Metal Disulfide Growth被引量：1
《Precision Chemistry》2024年第8期414-420,共7页Yuling Yin Jia Li Feng Ding 
the support of a High-Talent Grant from Shenzhen Institute of Advanced Technology(SIATSE3G0991010,2023);startup grant from Shenzhen Institute of Advanced Technology,Overseas Research Cooperation Funding of Tsinghua SIGS(HW2021006);China Postdoctoral Science Foundation(No.2023M743675).
The inert gold substrate is one of the most commonly used substrates for synthesizing transition metal dichalcogenides(TMDCs),while the growth mechanism of TMDCs on gold substrates in a sulfur-rich environment is stil...
关键词：MoS_(2) Au-S reconstruction Au substrate growth mechanism ALIGNMENT 
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