Shape linear peptides into rigid rings: a sp^3 C–H arylation approach to cyclophane-braced peptide macrocycles  

作　　者：Yuankun Dao Suwei Dong 

机构地区：[1]State Key Laboratory of Natural and Biomimetic Drugs, and Department of Chemical Biology, School of Pharmaceutical Sciences,Peking University

出　　处：《Science China Chemistry》2018年第12期1477-1478,共2页中国科学（化学英文版）

摘　　要：Peptide-based therapeutics have attracted increasing attention due to their unique properties in comparison to small molecule drugs and recombinant biologics [1].With moderate size and suitable surface area,peptides possess enormous potential in drug discovery for their promising capabilities of intercepting protein-protein interactions (PPIs),which is extremely difficult to be accomplished using small molecule compounds [2].

关 键 词：Shape linear PEPTIDES RIGID RINGS PEPTIDE macrocycles 

分 类 号：O6[理学—化学]