MutT同源酶1在乳腺导管内增生性病变及浸润性乳腺癌中的表达及意义  

EXPRESSION OF MUT T HOMOLOG 1 IN INTRADUCTAL PROLIFERATIVE LESION OF BREAST AND INVASIVE BREAST CANCER AND ITS CLINICAL SIGNIFICANCE

作　　者：刘剑桥 魏云龙 张鹏[3] 王超[3] 王晓春[3] Liu Jianqiao;Wei Yunlong;Zhang Peng(School Of Medicine,Hebei University,Baoding 071000,China)

机构地区：[1]河北大学医学院,河北省保定市071000 [2]保定市第一中心医院乳腺外科 [3]河北大学附属医院乳腺外科

出　　处：《中国煤炭工业医学杂志》2019年第1期1-5,共5页Chinese Journal of Coal Industry Medicine

基　　金：河北省卫生计生委医学科学研究计划项目(编号:ZD20140370)

摘　　要：目的探讨MutT同源酶1(MutThomolog1,MTH1)在乳腺导管内增生性病变及浸润性乳腺癌中的表达及与临床病理指标的关系。方法用免疫组化S-P法检测29例正常乳腺组织(normal breast tissues)、28例普通型导管增生(usual ductal hyperplasia,UDH)、23例柱状细胞病变(columnar cell lesions,CCL)、27例非典型导管增生(atypical ductal hyperplasia,ADH)、30例导管原位癌(ductal carcinoma in situ,DCIS)和67例浸润性乳腺癌(invasive breast cancer,IBC)中MTH1的表达情况。结果 MTH1蛋白在正常乳腺、UDH、CCL、ADH、DCIS、IBC中表达的总阳性率分别为10.3%(3/29)、32.1%(9/28)、52.2%(12/23)、59.3%(16/27)、90.0%(27/30)、93.3%(63/67),其表达水平之间差异有统计学意义(χ~2=84.968,P<0.001)。多组间两两比较结果显示,DCIS组和IBC组MTH1蛋白表达均高于正常乳腺组织(χ~2=37.435、65.974,P<0.005)、UDH组(χ~2=20.592、41.219,P<0.005)和CCL组(χ~2=9.583、21.598,P<0.005)。MTH1的表达与肿瘤大小、年龄、淋巴结是否转移、ER、PR、HER-2表达无明显相关性。结论对乳腺导管内增生性病变行MTH1检测有利于早期发现浸润性乳腺癌。通过监测乳腺导管内增生性病变中MTH1蛋白的表达判断病变可能发生恶性转化的风险,并可能通过应用MTH1抑制剂减少乳腺癌的发生。Objective To investigate the expression and clinic pathologic parameter of the Mut T homolog1 in intraductal proliferative lesion of breast and invasive breast cancer.Methods Immunohistochemistry was performed to detecte MTH 1 expression in29 cases of normal breast tissues,28 cases of usual ductal hyperplasia,23 cases of columnar cell lesions,27 cases of atypical ductal hyperplasia,30 cases of ductal carcinomainsitu insite and 67 cases of invasive breast cancer.Results Positive expression rates of MTH 1 in normal breast tissues,UDH,CCL,ADH,DCIS,IBC were 10.3%(3/29),32.1%(9/28),52.2%(12/23),59.3%(16/27),90.0%(27/30)and 93.3%(63/670),respectively,indicating a significant difference(χ^2=84.968,P<0.001).The expression of MTH 1 in DCIS or IBC was significantly higher than that in normal breast tissues(χ^2=37.435,65.974,P<0.005),UDH(χ^2=20.592,41.219,P<0.005)and CCL(χ^2=9.583,21.598,P<0.005).The expression of MTH 1 was not correlated with tumor size,age,lymphatic metastasis,estrogen receptor(ER),progesterone receptor(PR)and human epidermal growth factor receptor-2(HER-2).Conclusion The test of MTH 1 on intraductal proliferative lesion of breast can benefit an early exposure of breast cancer.It is feasible to evaluate the risky liability of invasive breast cancer from intraductal proliferative lesion of breast by monitoring the expression of MTH 1.The application of MTH 1 inhibitor may reduce the occurrence of invasive breast cancer.

关 键 词：MutT同源酶1 乳腺导管内增生性病变 氧化损伤 DNA复制 

分 类 号：R737.9[医药卫生—肿瘤]