Perturbations in Amino Acid Metabolism in Children with Kaschin-Beck Disease: A Study of Urinary Target Metabolomics  

作　　者：HU Jian WANG Yu Meng WANG Wei Yi ZHAO Zhi Jun LI Qiang WANG Li Hua 

机构地区：[1]The Center for Endemic Disease Control, Chinese Center for Disease Control and Prevention, Harbin Medical University [2]Qinghai Institute for Endemic Disease Prevention and Control

出　　处：《Biomedical and Environmental Sciences》2019年第1期34-37,共4页生物医学与环境科学（英文版）

基　　金：supported by the National Natural Science Foundation of China [Grant number:81372937]

摘　　要：Kaschin-Beck disease (KBD) is an endemic and chronic osteoarthropathy characterized by pathological aspects including chondrocyte degeneration, necrosis, progressive loss of articular cartilage, and secondary degenerative osteoarthrosis of epiphyseal cartilage, epiphyseal plate cartilage, and articular cartilage, during puberty[1]. The main clinical symptoms are limb joint pain, thickening, deformation, limited movement, muscle atrophy, and in case of more severely affected patients, short fingers (toes), short limbs, and even short stature[1].

关 键 词：Kaschin-Beck DISEASE (KBD) Chronic OSTEOARTHROPATHY Chondrocytic DEGENERATION 

分 类 号：Q[生物学]