Anti-tumor responses to hypofractionated radiation in mice grafted with triple negative breast cancer is associated with decorin induction in peritumoral muscles  

作　　者：Qi Yu Kedao Xin Yu Miao Zhaobin Li Shen Fu Shudong Hu Qing Zhang Shumin Zhou 

机构地区：[1]Department of Radiation Oncology,Fudan University Shanghai Cancer Center,Shanghai 200032,China [2]Department of Oncology,Shanghai Medical College,Fudan University,Shanghai 200032,China [3]Department of Radiation Oncology,Suzhou Science and Technology Town Hospital,Suzhou 215153,China [4]Department of Radiation Oncology,Shanghai Jiaotong University Affiliated Sixth People's Hospital,Shanghai 200233,China [5]Institute of Microsurgery on Extremities,Shanghai Jiaotong University Affiliated Sixth People's Hospital, Shanghai 200233,China [6]Department of Radiology,The Affiliated of Renmin Hospital,Jiangsu University, Zhenjiang 212002,China [7]Department of Radiation Oncology,Shanghai Proton and Heavy Ion Center, Shanghai 201321,China

出　　处：《Acta Biochimica et Biophysica Sinica》2018年第11期1150-1157,共8页生物化学与生物物理学报（英文版）

基　　金：the grants from the National Key R&D Program of China (No.2017YFC0107600),the National Natural Science Foundation of China (No.81773225);the Scientific Research Grant from Shanghai Municipal Commission of Health and Family Planning(No.20134051),the Interdisciplinary program of shanghai Tong University(No.YG2017MS21).

摘　　要：Triple negative breast cancer (TNBC)is the most lethal one for all types of breast cancer.Though radiotherapy is an efficient treatment,long-term survival rate of TNBC patients is still suboptimal. Hyprofractionated radiotherapy,an improved radiotherapy,has made an inspiring result in clinic. However,the mechanism underlying TNBC treated with hyprofractionated radiotherapy is not clear.Decorin (DCN)is a small poteoglycan of matrix which has an inhibitory effect on the breast cancer and is secreted by muscle under certain conditions.In this study,we demonstrated that peritumoral muscles secrete more DCN at higher dose irradiation than that at conventional irradiation dose in TNBC tumor-bearing mice.Thus,it indicates that DCN secreted from peritumoral muscle may be one of the reasons why hyprofractionated radiotherapy could inhibit the growth of TNBC more effectively.Moreover,we also indicated that the up-regulated DCN attenuated lung metastasis of TNBC.In conclusion,we demonstrated that hypofractionated radiation promotes the secretion of DCN in peritumoral muscle,thus enhancing the inhibitory effect on TNBC,which might help to optimize the strategy of radiotherapy for TNBC patients in the future.

关 键 词：hyprofractionated RADIOTHERAPY triple negative breast cancer DECORIN PERITUMORAL MUSCLE 

分 类 号：Q[生物学]