Diterpenoids from the aerial parts of Leonurus macranthus  

作　　者：Yunfang Zhao Zheng Huang Jing Sun Daoran Pang Xiaonan Chen Huina Yao Zhixiang Zhu Jiao Zheng Pengfei Tu Jun Li 

机构地区：[1]Modern Research Center for Traditional Chinese Medicine, School of Chinese Materia Medica, Beijing University of Chinese Medicine

出　　处：《Chinese Chemical Letters》2019年第1期47-50,共4页中国化学快报（英文版）

基　　金：financially supported by the National Natural Science Foundation of China (Nos. 81573572, 81530097);New Century Excellent Talents in University (No. NCET-13-0693)

摘　　要：Four new diterpenoids including one cis clerodane-type(1) and three highly oxygenated labdane-type diterpenes(2–4) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic data(NMR, UV, IR, and MS). Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus. Compounds 1 and 4 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC_(50) values of 35.8 ± 3.6 mmol/L and 48.6 ± 4.8 mmol/L,Four new diterpenoids including one cis clerodane-type(1) and three highly oxygenated labdane-type diterpenes(2–4) were isolated from the aerial parts of Leonurus macranthus. Their structures were elucidated on the basis of spectroscopic data(NMR, UV, IR, and MS). Compound 1 represents the first example of cis clerodane-type diterpene in the plants of Leonurus genus. Compounds 1 and 4 exhibited weak inhibition of nitric oxide production in lipopolysaccharide-stimulated BV-2 microglial cells with IC_(50) values of 35.8 ± 3.6 mmol/L and 48.6 ± 4.8 mmol/L, respectively

关 键 词：Lamiaceae LABDANE DITERPENOID cis-Clerodane DITERPENOID Anti-neuroinflammation 

分 类 号：O6[理学—化学]