多巴胺D4受体基因rs1800955多态性与负性生活事件的交互作用对蒙古族青少年人格特征的影响  

The interaction between DRD4 gene rs1800955 polymorphism and negative life events on the personality characteristics of Mongolian adolescents

作　　者：黄鑫鑫 李玉玲[1] 恩和巴雅尔[1] Huang Xinxin;Li Yuling;Enherbayaer(Institute of Life Science and Technology,Inner Mongolia Normal University,Hohhot 010022,China)

机构地区：[1]内蒙古师范大学生命科学与技术学院,呼和浩特010022

出　　处：《中华行为医学与脑科学杂志》2019年第1期70-74,共5页Chinese Journal of Behavioral Medicine and Brain Science

基　　金：国家自然科学基金项目(31260265);内蒙古师范大学科研基金项目(2013ZRYB21).

摘　　要：目的探讨多巴胺D4受体(dopamine D4 receptor,DRD4)基因rs1800955多态性与负性生活事件的交互作用对蒙古族青少年人格特征的影响。方法对239名12~15岁蒙古族青少年采用艾森克人格问卷和青少年生活事件自评量表进行测评,并用改良多重连接酶反应(improved multiple ligase detection reaction,iMLDR)技术测定DRD4基因rs1800955多态性。结果(1)DRD4基因rs1800955多态性与精神质得分显著相关,携带CC基因型的个体精神质得分[(4.94±3.191)分]高于TT基因型[(3.38±2.29)分],差异有统计学意义(P<0.05)。(2)蒙古族青少年P(精神质)及N(神经质)得分与负性生活事件各因子均呈正相关(r=0.154~0.375,P<0.05或0.01)。(3)DRD4基因rs1800955多态性与负性生活事件的交互作用对蒙古族青少年精神质得分影响显著(CC基因型与人际关系交互作用:B=-2.689,95%CI=-4.589~0.789,χ2=7.695,P<0.01),在携带CC基因型个体中,人际关系因子高分者的精神质得分[(3.01±0.71)分]明显高于人际关系因子低分者[(2.61±0.67)](t=-3.066,P<0.01)。结论DRD4基因rs1800955多态性及其与人际关系因子共同作用于蒙古族青少年精神质,其CC基因型是精神质的危险基因,人际关系不良会增加CC基因型个体的风险。Objective To investigate the interaction between rs1800955 polymorphism of dopamine D4 receptor(DRD4) gene and negative life events on personality characteristics of Mongolian adolescents. Methods A total of 239 Mongolian adolescents aged 12-15 were assessed with Eysenck Personality Questionnaire(EPQ) and Adolescent Self-Rating Life Events Check List(ASLEC). The polymorphism of DRD4 gene rs1800955 was determined by improved multiple ligase detection reaction(iMLDR) technique. Results (1) The rs1800955 polymorphism of DRD4 gene was significantly correlated with psychoticism score of EPQ.The psychoticism score of individuals with CC genotype (4.94 ± 3.19) was higher than that of TT genotype (3.38±2.29), and the difference was statistically significant (P<0.05). (2) The scores of psychoticism and neuroticism in Mongolian adolescents were positively correlated with the factors of negative life events(r=0.154-0.375, P<0.05 or 0.01) .(3) The interaction between the rs1800955 polymorphism of DRD4 gene and negative life events significantly affected the scores of psychoticism in Mongolian adolescents (CC genotype x interpersonal factor: B=-2.689, 95%CI=-4.589--0.789, χ2=7.695, P<0.01). In individuals with CC genotype, the scores of psychoticism in those with high scores of interpersonal relationship factors were significantly higher than those with low scores of interpersonal relationship factors((3.01±0.71) vs (2.61±0.67);t=-3.066, P<0.01). Conclusion The polymorphism of DRD4 gene rs1800955 and its association with interpersonal factors play an important role in the psychoticism of Mongolian adolescents.The CC genotype is a risk factor of psychoticism, and the poor interpersonal relationship may increase the risk of individuals with CC genotype.

关 键 词：蒙古族青少年 多巴胺D4受体基因 rs1800955多态性 负性生活事件 人格特征 

分 类 号：B844.2[哲学宗教—发展与教育心理学]