A single circular chromosome yeast  

作　　者：Yangyang Shao Ning Lu Chen Cai Fan Zhou Shanshan Wang Zhihu Zhao Guoping Zhao Jin-Qiu Zhou Xiaoli Xue Zhongjun Qin 

机构地区：[1]Key Laboratory of Synthetic Biology,CAS Center for Excellence in Molecular Plant Sciences,Shanghai Institute of Plant Physiology and Ecology,Chinese Academy of Sciences,200032 Shanghai,China [2]University of Chinese Academy of Sciences,100049 Beijing,China [3]The State Key Laboratory of Molecular Biology,CAS Center for Excellence in Molecular Cell Science,Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,200031 Shanghai,China [4]School of Life Science and Technology,ShanghaiTech University,201210 Shanghai,China [5]Wuhan Frasergen Bioinformatics Co,430075 Wuhan,China [6]Beijing Institute of Biotechnology,100071 Beijing,China [7]Shanghai-MOST Key Laboratory of Health and Disease Genomics,Chinese National Human Genome Center at Shanghai,201203 Shanghai,China [8]Department of Microbiology and Li Ka Shing Institute of Health Sciences,The Chinese University of Hong Kong,Prince of Wales Hospital,Shatin,New Territories,Hong Kong SAR,China [9]State Key Laboratory of Genetic Engineering,Department of Microbiology,School of Life Sciences and Institute of Biomedical Sciences,Fudan University,200032 Shanghai,China

出　　处：《Cell Research》2019年第1期87-89,共3页细胞研究（英文版）

基　　金：grants from Chinese Academy of Sciences (XDB19000000);National Natural Science Foundation of China (3183010S, 31770099,31521061);Ministry of Science and Technology (2016YFA0500701).

摘　　要：Dear editor,Most of the prokaryotic cells contain a single circular chromosome.In contrast, the eukaryotic cells usually contain multiple linear chromosomes. Recently, we artificially created a single linear chromosome yeast strain SY14 from native 16 chromosomes in a haploid Saccharomyces cerevisiae, which displays minor fitness defects.^1 In this study, we have created a new yeast strain which contains a single circular chromosome and apparently has not been found in nature.

关 键 词：PROKARYOTIC cells SACCHAROMYCES CEREVISIAE 

分 类 号：Q[生物学]