This work was supported by the Science&Technology Fundamental Resources Investigation Program(2022FY101100);the Strategic Priority Research Program of the Chinese Academy of Sciences(Precision seed design and breeding)(XDA24020101);the National Natural Science Foundation of China(Nos.31970544,31970545,32022003,32150020,32200057,and 32270092);the Youth Innovation Promotion Association of CAS(No.2020090);the China National Postdoctoral Program for Innovative Talents(BX20220331);the China Postdoctoral Science Foundation(2022M720160);the Special Research Assistant Program of Chinese Academy of Sciences(No.2023000056).
Prokaryotic Argonautes(pAgos)provide bacteria and archaea with immunity against plasmids and viruses.Catalytically active pAgos utilize short oligonucleotides as guides to directly cleave foreign nucleic acids,while i...
financially supported by the Ningbo Science and Technology Bureau,China (Nos.2021S018 and 2022Z169);the National Natural Science Foundation of China (No.42077026)
Coastal marshes are transitional areas between terrestrial and aquatic ecosystems.They are sensitive to climate change and anthropogenic activities.In recent decades,the reclamation of coastal marshes has greatly incr...
supported by the National Key Research and Development Program of China(2021YFD1500300);the Key-Area Research and Development Program of Guangdong Province(2022B0202110001);the National Natural Science Foundation of China(92251302,32200007 and 32370011);the Guangdong Provincial Science and Technology Plan Project(2022A0505020001);the Xinjiang Uygur Autonomous Region Tianchi Talent Introduction Plan(‘TianChi Excellence Award for Young Doctoral Talents’)and the China Postdoctoral Science Foundation(2023M733725).
Prokaryotes are ubiquitous in the biosphere,important for human health and drive diverse biological and environmental processes.Systematics of prokaryotes,whose origins can be traced to the discovery of microorganisms...
The recent discovery of the CRISPR-Cas-mediated acquired immunity system highlights the fact that our knowl-edge of phage/virus defense mechanisms encoded in bacterial and archaeal genomes is far from complete.Indeed,...
supported by the grants from the Ministry of Science and Technology of China(No.2021YFA0804700);National Natural Science Foundation of China(Grant Nos.32370744 and 32350710195);Shanghai Science and Technology Commission(No.20JC1410500);UK Medical Research Council(Grant Nos.MC_UU_12021/3 and MC_U137788471)for grants to J.L.L.
Cytidine triphosphate synthase(CTPS)plays a pivotal role in the de novo synthesis of cytidine triphosphate(CTP),a fundamental building block for RNA and DNA that is essential for life.CTPS is capable of directly bindi...
support from the Senior User Project of RV KEXUE(Grant No.KEXUE2019GZ05);the Center for Ocean Mega-Science,Chinese Academy of Sciences;funding support from the Second Tibetan Plateau Scientific Expedition and Research Program(Grant No.2021QZKK0100);the National Key R&D Program of China(Grant No.2022YFF1002801);the National Natural Science Foundation of China(Grant No.92251302).
Cold seeps in the deep sea are closely linked to energy exploration as well as global climate change.The alkane-dominated chemical energy-driven model makes cold seeps an oasis of deep-sea life,showcasing an unparalle...
Prokaryotic organisms have evolved sophisticated immune systems for self-protection to resist bacteriophage invasion.With further research on prokaryotic immune systems,several important molecular biology tools have b...
supported by the National Natural Science Foundation of China(No.42077219);the Ningbo Municipal Natural Science Foundation(No.2019A610443);the Hangzhou Municipal Agriculture and Social Development Project(No.2020ZDSJ0697);the Fundamental Research Funds for the Provincial Universities of Zhejiang(No.SJLY2020011)
Globally,various types of pollution affect coastal waters as a result of human activities.Bioaugmentation and biostimulation are effective methods for treating water pollution.However,few studies have explored the res...
supported by the Ministry of Science and Technology(2020YFA0907700);National Natural Science Foundation of China(31770078,32270051);Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(21TQ1400204).
Mesophilic Argonautes(Agos)from microbial resources have received significant attention due to their potential applications in genome editing and molecular diagnostics.This study characterizes a novel Ago from Pseudob...
supported by grants from National Key R&D Program of China(Grant No.2021YFA1300900 to JL:2022YFC2302900 to HY);the Lingang Laboratory(Grant No LG202101-01-08);Shanghai Municipal Commission of Science and Technology(Grant No.22ZR1441600 to JL,ZD2021CY001 to HY)and the Shanghai Frontiers Science Center for Biomacromolecules and Precision Medicine,ShanghaiTech University.
DearEditor,Heme is an essential cofactor required across all kingdoms of life utilized in numerous biological processes,including cellular respiration.CydDC is a prokaryotic ATP-binding cassette(ABC)transporter requir...