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作品数：60被引量：145H指数：8
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相关机构：扬州大学中国科学院新疆生产建设兵团绵羊繁育生物技术重点实验室石河子大学更多>>
相关期刊：《中国生物学文摘》《特别健康（下）》《Science China(Life Sciences)》《Science China Chemistry》更多>>
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A High-Affinity Methyl-CpG-Binding Protein for Endonuclease-Free and Label-Free DNA Methyltransferase Activity Detection
《Journal of Analysis and Testing》2024年第3期327-334,共8页Yang Bai Shulin Tan Yingsong Sheng Yueqing Gu Haiping Wu Baicun Li Yunlong Liu 
funded by the National Natural Science Foundation of China(61901527,82300051);National Key Research and Development Program of China(2022YFF0710803,2022YFF0710800);Fundamental Research Funds for the Central Universities(2632021ZD02).
DNA methyltransferase(MTase)activity detection has received increasing attention as a promising biomarker and therapeutic target.However,most of these detection methods rely on endonuclease digestion and signal groups...
关键词：DNA methyltransferase Methyl-CpG-binding protein Surface plasmon resonance Inhibitor screening BIOSENSING 
IS607 TnpB is a hypercompact RNA-guided DNA endonuclease
《Cell Research》2024年第7期473-474,共2页Hui Yang Dinshaw J.Patel 
The Zhiwei Huang lab report on a hypercompact IS607 TnpB protein that naturally co-occurs with the conserved RAGATH-18 RNA,thereby identifying a new family of compact RNAguided DNA endonucleases.Such an IS607 TnpB-bas...
关键词：thereby EDITOR INSERTION 
Genome editing in plants using the TnpB transposase system被引量：1
《aBIOTECH》2024年第2期225-230,共6页Qi Li Yongqiang Wang Zhuoting Hou Hang Zong Xuping Wang Yong EZhang Haoyi Wang Haitao Chen Wen Wang Kang Duan 
The widely used clustered regularly interspaced short palindromic repeats(CRISPR)/CRISPR-associated nuclease(Cas)system is thought to have evolved from IS200/IS605 transposons.TnpB proteins,encoded by one type of IS20...
关键词：ISAam1 ISDra2 ISYmu1 Plant genome editing Rice TnpB transposon endonuclease 
Characterization of argonaute nucleases from mesophilic bacteria Pseudobutyrivibrio ruminis
《Bioresources and Bioprocessing》2024年第1期1244-1256,共13页Xiaoyi Xu Hao Yang Huarong Dong Xiao Li Qian Liu Yan Feng 
supported by the Ministry of Science and Technology(2020YFA0907700);National Natural Science Foundation of China(31770078,32270051);Shanghai Pilot Program for Basic Research-Shanghai Jiao Tong University(21TQ1400204).
Mesophilic Argonautes(Agos)from microbial resources have received significant attention due to their potential applications in genome editing and molecular diagnostics.This study characterizes a novel Ago from Pseudob...
关键词：Pseudobutyrivibrio ruminis Argonaute Mesophilic Argonaute Prokaryotic Argonaute ENDONUCLEASE DNA cleavage 
PA-E18G substitution in influenza A virus confers resistance to ZX-7101,a cap-dependent endonuclease inhibitor被引量：2
《Virologica Sinica》2023年第4期559-567,共9页Dan Luo Qing Ye Rui-Ting Li Hang-Yu Zhou Jing-Jing Guo Suo-Qun Zhao Sen Zhang Tao Jiang Yong-Qiang Deng Cheng-Feng Qin 
supported by the National Science and Technology Major Project (2018ZX097110003-005-002);the Key-Area Research and Development Program of Guangdong Province (2022B1111020002);the National Natural Science Foundation of China (NSFC) (32170159,and 82174055);supported by the National Science Fund for Distinguished Young Scholars (81925025);the Innovative Research Group (81621005)of the NSFC;the Innovation Fund for Medical Sciences (2019-I2M-5-049)of the Chinese Academy of Medical Sciences.
Cap-dependent endonuclease(CEN)in the polymerase acidic protein(PA)of influenza A virus(IAV)represents a promising drug target due to its critical role in viral gene transcription.The CEN inhibitor,baloxavir marboxil(...
关键词：Influenza virus Cap-dependent endonuclease(CEN) Baloxavir marboxil(BXM) Drug resistance 
Programmable endonuclease combined with isothermal polymerase amplification to selectively enrich for rare mutant allele fractions
《Chinese Chemical Letters》2022年第8期4126-4132,共7页Junman Chen Tian Qiu Michael G.Mauk Zheng Su Yaguang Fan Dennis J.Yuan Qinghua Zhou Youlin Qiao Haim H.Bau Jianming Ying Jinzhao Song 
supported by China Scholarship Council;NIH grant to the University of Pennsylvania(No.K011K01TW011190-01A1);NIH grant to the University of Pennsylvania(No.R21CA228614-01A1);Beijing Hope Run Special Fund from the Cancer Foundation of China(Nos.LC2019L04 and LC2020A36)。
Liquid biopsy is a highly promising method for non-invasive detection of tumor-associated nucleic acid fragments in body fluids but is challenged by the low abundance of nucleic acids of clinical interest and their se...
关键词：Mutant allele enrichment Programmable endonuclease Liquid biopsy Mutation detection Point-of-care testing CRISPR-Cas9 Recombinase polymerase amplification Nucleic acid diagnostics 
Sensitive detection of alkaline phosphatase based on terminal deoxynucleotidyl transferase and endonuclease Ⅳ-assisted exponential signal amplification
《Journal of Pharmaceutical Analysis》2022年第4期692-697,共6页Weicong Ye Longjie Li Zishan Feng Bocheng Tu Zhe Hu Xianjin Xiao Tongbo Wu 
financially supported by the National Natural Science Foundation of China(Grant No.:21904045);the Fundamental Research Funds for the Central Universities(HUST:Grant No.:2019kfyXJJS169);Training Program of Innovation and Entrepreneurship for Undergraduates of Hubei Province(Grant No.:S202010487225).
Alkaline phosphatase(ALP)is widely expressed in human tissues.ALP plays an important role in the dephosphorylation of proteins and nucleic acids.Therefore,quantitative analysis of ALP plays a vital role in disease dia...
关键词：Alkaline phosphatase Terminal deoxynucleotidyl TRANSFERASE EndonucleaseⅣ Exponential amplification 
Alternative end-joining in BCR gene rearrangements and translocations被引量：2
《Acta Biochimica et Biophysica Sinica》2022年第6期782-795,共14页Wanyu Bai Bo Zhao Mingyu Gu Junchao Dong 
the grants from the National Natural Science Foundation of China(Nos.,81871304,32070892);Guangdong Innovative and Entrepreneurial Research Team Program(No.,2016ZT06S252);Guangzhou Municipal Science and Technology Bureau(No.,202002030064);the Fundamental Research Funds for the Central Universities(No.,18ykzd11);Sanming Project of Medicine in Shenzhen(No.,SZSM202011004);Open project of Key Laboratory of Tropical Disease Control(Sun,Yat-sen,University);Ministry of Education(No.,2020ZX01)。
Programmed DNA double-strand breaks(DSBs)occur during antigen receptor gene recombination,namely V(D)J recombination in developing B lymphocytes and class switch recombination(CSR)in mature B cells.Repair of these DSB...
关键词：classical nonhomologous end-joining alternative end-joining V(D)J recombination chromosomal translocation DSB end resection ENDONUCLEASE 
Probing and modulating the interactions of the DNAzyme with DNA-functionalized nanoparticles被引量：1
《Chinese Chemical Letters》2022年第6期3026-3030,共5页Yuqiang Hu Zhen Zhang Wei Zhang Minghao Hu Xianjin Xiao Tongbo Wu 
the National Natural Science Foundation of China (Nos. 82172372 and 21904045);COVID-19 Pneumonia Emergency Scientific Research Special Fund of Wuhan (No. EX20D03);the Fundamental Research Funds for the Central Universities (Nos. 2019kfy XJJS169 and 2021yjs CXCY127)。
DNA-functionalized gold nanoparticles are one of the most versatile bionanomaterials for biomedical and clinical diagnosis. Herein, we discovered that the performance of DNAzyme cleaving the substrate is highly relate...
关键词：Gold nanoparticles DNAZYME Interface interaction Rate difference Human apurinic/apyrimidinic endonuclease 1 
Shared-probe system:An accurate,low-cost and general enzyme-assisted DNA probe system for detection of genetic mutation
《Chinese Chemical Letters》2022年第6期3043-3048,共6页Lida Ren Zhihao Ming Wei Zhang Yangwei Liao Xiaofeng Tang Bei Yan Huimin Lv Xianjin Xiao 
the National Natural Science Foundation of China(Nos.21705053 and 81871732);the Natural Science Foundation of Hubei Province(No.2017CFB117);Hubei Province Health and Family Planning Scientific Research Project(No.J2017Q017);Wuhan Youth Science and Technology Plan(No.2017050304010293)。
Enzyme assisted DNA probes are powerful tools in molecular diagnostics for their simplicity,rapidity,and low detection limit.However,cost of probes,difficulty in optimization and disturbance of secondary structure hin...
关键词：Nucleic acid probe EndonucleaseⅣ Secondary structure Genomic mutation SNP detection 
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