Transcriptome-wide reprogramming of N^6-methyladenosine modification by the mouse microbiome  

作　　者：Xiaoyun Wang Yan Li Wenjun Chen Hailing Shi A.Murat Eren Aleksey Morozov Chuan He Guan-Zheng Luo Tao Pan 

机构地区：[1]Department of Biochemistry and Molecular Biology,The University of Chicago,Chicago,IL 60637,USA [2]State Key Laboratory of Biocontrol,School of Life Sciences,Sun Yat-sen University, Guangzhou,Guangdong 510275,China [3]Department of Molecular Genetics and Cell Biology,The University of Chicago,Chicago,IL 60637,USA [4]Department of Chemistry,The University of Chicago, Chicago,IL 60637,USA [5]Howard Hughes Medical Institute,The University of Chicago,Chicago,IL 60637,USA [6]Department of Medicine,The University of Chicago,Chicago,IL 60637,USA [7]Marine Biological Laboratory,Woods Hole,MA 02543,USA.

出　　处：《Cell Research》2019年第2期167-170,共4页细胞研究（英文版）

基　　金：National Institutes of Health (K01 DKI 11764 to XYW,RMI HGO08935 to TP);DoD/CDMRP (BC160450 to TP);the Natlonal Natural Science Foundation of China (31741033 and 91753129 to GZL).

摘　　要：Dear Editor, Microbiome affects many aspects of human health and disease and elicits a wide range of host responses including remarkable epigenetic changes such as DNA methylation,histone modification and non-coding RNA expression.A still poorly explored area of microbiome-host interaction is the response of host RNA modification.N^6-methyladenosine (m^6A)is the most abundant mRNA modification in mammalian cells,occurring at -3 modified adenosine residues per transcript.

关 键 词：DEAR EDITOR MICROBIOME AFFECTS human health 

分 类 号：Q[生物学]