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Storage time affects the level and diagnostic efficacy of plasma biomarkers for neurodegenerative diseases: 《Neural Regeneration Research》2025年第8期2373-2381,共9页Lifang Zhao Mingkai Zhang Qimeng Li Xuemin Wang Jie Lu Ying Han Yanning Cai; supported by the National Key Research&Development Program of China,Nos.2021YFC2501205(to YC),2022YFC24069004(to JL);the STI2030-Major Project,Nos.2021ZD0201101(to YC),2022ZD0211800(to YH);the National Natural Science Foundation of China(Major International Joint Research Project),No.82020108013(to YH);the Sino-German Center for Research Promotion,No.M-0759(to YH);a grant from Beijing Municipal Science&Technology Commission(Beijing Brain Initiative),No.Z201100005520018(to JL)。; Several promising plasma biomarker proteins,such as amyloid-β(Aβ),tau,neurofilament light chain,and glial fibrillary acidic protein,are widely used for the diagnosis of neurodegenerative diseases.However,little is k...; 关键词：Alzheimer’s disease amyloid-β diagnostic ability glial fibrillary acidic protein NEURODEGENERATION neurofilament light chain plasma biomarkers single molecule array storage time tau

Inhibition of IGF-1Rαaffects the differentiation fate of rat optic cup-derived retinal stem cells to retinal ganglion cells in vitro: 《International Journal of Ophthalmology(English edition)》2025年第4期582-589,共8页Qi-You Li Xiao-Ling Tan Hai-Wei Xu Yu-Xiao Zeng Xiao-Yong Huang; AIM:To explore the impact of insulin-like growth factor-1 receptorα(IGF-1Rα)on the differentiation fate of optic-cupderived retinal stem cells(OC-RSCs)into retinal ganglion cells(RGCs)in vitro.METHODS:OC-RSCs were i...; 关键词：insulin-like growth factor-1 receptorα retinal ganglion cell rat optic cup retinal stem cells differentiation fate

How Work Affects the Mental Health of Postdocs?——An Analysis Based on Nature’s 2020 Global Postdoc Survey Data: 《International Journal of Mental Health Promotion》2025年第4期422-450,共29页Li Yang Wanlin Cai Wenke Wang Chuanyi Wang; Background:Thepostdoctoral workforce has been expanding worldwide,playing a vital role in scientific progress,innovation,and knowledge dissemination.Nevertheless,their mental health is also increasingly a global conce...; 关键词：Postdocs mental health work-life balance satisfaction

Overexpression of rbk affects the biofilm formation, adhesion, and metabolic profile of Lactiplantibacillus paraplantarum LR-1: 《微生物学报》2025年第3期1241-1265,共25页YANG Yao SONG Yunlong CHEN Xing LI Xiaoli LONG Haiqi LIU Lei RAO Yu; 四川省科技计划重点研发项目(2023YFN0058);四川省自然科学基金(2023NSFSC1203);甘肃省科技重大专项(23ZDNA007)。; [Objective]Biofilm formation and adhesion are important indicators for evaluating the beneficial effects of probiotics.However,the relationship of specific genes with the biofilm formation and adhesion of Lactiplantib...; 关键词：Lactiplantibacillus rbk overexpression BIOFILM ADHESION untargeted metabolomics

Natural variation of CT2 affects the embryo/kernel weight ratio in maize: 《Journal of Genetics and Genomics》2025年第3期432-440,共9页Yumin Zhang Sihan Zhen Chunxia Zhang Jie Zhang Xiaoqing Shangguan Jiawen Lu Qingyu Wu Lynnette M.A.Dirk A.Bruce Downie Guoying Wang Tianyong Zhao Junjie Fu; supported by National Key Research and Development Program of China(2023YFF1000400);National Natural Science Foundation of China(32101693);Key Research and Development Program of Shaanxi(2021ZDLNY01-06);Agricultural Science and Technology Innovation Program of CAAS(CAAS-ZDRW202004);supported by Hatch project(1019088).; Embryo size is a critical trait determining not only grain yield but also the nutrition of the maize kernel.Up to the present,only a few genes have been characterized affecting the maize embryo/kernel ratio.Here,we id...; 关键词：MAIZE Embryo size GWAS CT2 Natural variation

C1ql3 knockout affects microglia activation, neuronal integrity, and spontaneous behavior in Wistar rats: 《Animal Models and Experimental Medicine》2025年第2期332-343,共12页Li Zhang Wei Dong Jingwen Li Shan Gao Hanxuan Sheng Qi Kong Feifei Guan Lianfeng Zhang; The present work was supported by the National Natural Science Foundation(31970508);the National Key Research and Development Program of China(2022YFF0710702).; Background:C1QL3 is widely expressed in the brain and is specifically produced by a subset of excitatory neurons.However,its function is still not clear.We established C1ql3-deficient rats to investigate the role of C...; 关键词：C1QL3 KNOCKOUT MICROGLIA NEURON rat

MePHD1.2 affects the synthesis of cyanogenic glycosides by regulating transcription of MeCYP79D2 in cassava: 《The Crop Journal》2025年第1期204-214,共11页Mengtao Li Xiao Zhao Yajun Li Yuanchao Li Xiaoye Zhao Weitao Mai Luqman Khan Qibing Liang Qingchun Yin Wenquan Wang Jinping Liu Xin Chen; supported by grants from the National Natural Science Foundation of China(32460505);China Agriculture Research System(CARS-11);the Chinese Academy of Tropical Agricultural Sciences for the Science and Technology Innovation Team of the National Tropical Agricultural Science Center(CATASCXTD202301);Additional support was provided by the Hainan Province Graduate Innovation Research Project(Hyb2020-09);the Key Laboratory of Tropical Fruits and Vegetables Quality and Safety for State Market Regulation(KF-2023016).; The high content of cyanogenic glycosides(CG)in cassava tubers affects food safety.CG are involved in the plant growth and development and protect cassava leaves from herbivorous predators.However,the regulatory mecha...; 关键词：Cyanogenic glycosides Cytochrome P450 Manihot esculenta MePHD1.2

TKN3 affects cell expansion to regulate fruit development in tomato: 《Horticultural Plant Journal》2025年第1期251-263,共13页Shuai Sun Yaqin Yuan Meng Xu Zhiqiang Liu Xiaowei Yuan Xingsheng Li Ren Li Xia Cui; supported by The National Key Research and Development Program of China(Grant No.2022YFF1003002);the National Natural Science Foundation of China(Grant No.32120103010);the Project of Yuandu Industry Leading talent。; Tomato is a model system for studying fleshy fruit development.After fertilization,cell division and expansion in the pericarp are crucial for fruit development and determine the final fruit size.TKN3 was found to be ...; 关键词：Solanum lycopersicum TKN3 Tomato fruits Cell expansion BELLs Transcription factor

The circadian clock affects starvation resistance through the pentose phosphate pathway in silkworm,Bombyx mori: 《Insect Science》2025年第1期55-68,共14页Tai-Ming Dai Jian-Feng Qiu Cheng Luo Wen-Zhao Cui Kai Liu Jiang-Lan Li Ruji Peng Yang-Hu Sima Shi-Qing Xu; supported by the National Natural Science Foundation of China(Grant No.32172794 to S.-Q.X.and 32302817 to J.-F.Q.);the Priority Academic Program Development of Jiangsu Higher Education Institutions(PAPD to S.-Q.X.);Postgraduate Research&Practice Innovation Program of Jiangsu Province(KYCX23_3259 to R.-J.P)。; Disruption of the circadian clock can affect starvation resistance,but the molecular mechanism is still unclear.Here,we found that starvation resistance was significantly reduced in the core gene BmPer deficient mutan...; 关键词：Bombyx mori circadian clock oxidative stress pentose phosphate pathway starvationresistance

Water deficit affects the nitrogen nutrition index of winter wheat under controlled water conditions: 《Journal of Integrative Agriculture》2025年第2期724-738,共15页Ben Zhao Anzhen Qin Wei Feng Xinqiang Qiu Pingyan Wang Haixia Qin Yang Gao Guojie Wang Zhandong Liu Syed Tahir Ata-Ul-Karim; supported by the National Natural Science Foundation of China(51609247);the Henan Provincial Natural Science Foundation,China(222300420589,202300410553);the Central Public-interest Scientific Institution Basal Research Fund,China(FIRI2022-22);the Science&Technology Fundamental Resources Investigation Program,China(2022FY101601);the Science and Technology Project of Xinxiang City,Henan Province,China(GG2021024);the Major Special Science and Technology Project of Henan Province,China(221100110700);the Joint Fund of Science and Technology Research and Development Plan of Henan Province,China(Superior Discipline Cultivation)(222301420104)。; Nitrogen(N)uptake is regulated by water availability,and a water deficit can limit crop N responses by reducing N uptake and utilization.The complex and multifaceted interplay between water availability and the crop N...; 关键词：critical nitrogen concentration shoot biomass plant nitrogen accumulation soil nitrate N concentration soil water content

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