Efficient base editing in G/C-rich regions to model androgen insensitivity syndrome  

作　　者：Jianan Li Zhen Liu Shisheng Huang Xiao Wang Guanglei Li Yuting Xu Wenxia Yu Shanshan Chen Yu Zhang Hanhui Ma Zunfu Ke Jia Chen Qiang Sun Xingxu Huang 

机构地区：[1]School of Life Science and Technology,ShanghaiTech University, 201210 Shanghai,China [2]Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,200031 Shanghai,China [3]University of Chinese Academy of Sciences,100049 Beijing,China [4]Institute of Neuroscience,Chinese Academy of Sciences (CAS)Key Laboratory of Primate Neurobiology,CAS Center for Excellence in Brain Science and Intelligence Technology,Chinese Academy of Sciences,200031 Shanghai,China [5]International Academy of Optoelectronics at Zhaoqing,South China Normal University,526060 Guangdong,China [6]Department of Pathology,The First Affiliated Hospital,Sun Yat-Sen University,Guangzhou,510080 Guangdong, China [7]CAS Center for Excellence in Molecular Cell Science, Shanghai Institute of Biochemistry and Cell Biology,Chinese Academy of Sciences,200031 Shanghai,China

出　　处：《Cell Research》2019年第2期174-176,共3页细胞研究（英文版）

摘　　要：Dear Editor, Most disease-associated genomic mutations are base substitutions and approximately half of pathogenic human single nucleotide polymorphisms (SNPs)are related to C-to-T substitutions in the ClinVar database.Base editors (BEs),which combine Casg-DIOA nickase and APOBEC (apolipoprotein B mRNA editing enzyme,catalytic polypeptide-like)or AID (activation-induced deaminase)cytidine deaminase family members, have been successfully applied to mediate C-to-T conversion in vitro and in vivo, providing a powerful tool to model or repair diseaserelated human SNPs.

关 键 词：DEAR Editor disease-associated GENOMIC MUTATIONS EFFICIENT BASE EDITING 

分 类 号：Q[生物学]