脂肪肝与肝纤维化关系的实验研究  

Experimental study on the correlation between fatty liver and hepatic fibrosis

作　　者：李靖环[1] 弓青梅 杨栓平[3] 王志平[3] 郝一彬[3] 

机构地区：[1]山西职工医学院,030012 [2]山西煤炭职工医院 [3]山西医科大学

出　　处：《山西医药杂志》2002年第2期111-112,共2页Shanxi Medical Journal

摘　　要：目的　探讨高脂性脂肪肝与肝纤维化之间的关系。方法　以高脂饮食饲喂 Wistar大鼠 3个月和6个月诱发高脂性脂肪肝模型 ,观察肝脏组织病理学变化 ,测定肝内甘油三酯 (TG)、羟脯氨酸 (H yp)的含量和血浆层粘蛋白 (L N)、透明质酸 (HA)的含量。结果　与对照组相比 ,模型 1组和 2组大鼠肝细胞内有大量的脂滴 ,但间质中无纤维组织。肝内 TG显著增高 ,而 Hyp、L N、H A的含量无明显增加。结论　高脂性脂肪肝与肝纤维化之间并无直接关系 ;脂肪肝是否合并肝纤维化可能与病因、病情缓急。Objective To explore the correlation between fatty liver and hepatic fibrosis.Methods Thirty Wistar rats were randomized into three groups:normal control group (group Ⅰ),sacrificed for three months with high fat diet group (group Ⅱ),sacrificed for six months with high fat diet group (group Ⅲ).Hepatic histopathological change was observed.Hepatic triglyceride (TG),hydroproline (Hyp) and plasma laminin (LN),hyaluronic acid (HA) contents were measured.Results As compared with group Ⅰ,steatosis was observed,but no fibre tissue observed in the liver in group Ⅱ,Ⅲ animals.Hepatic TG content was increased significantly,but Hyp,LN and HA content was not increased significantly in group Ⅱ,Ⅲ animals.Conclusion There is no direct relationship between fatty liver and hepatic fibrosis on the chronical high fat diet.The problem whether fatty liver is complicated by fibrosis may involve many factors such as cause,course,and state of the disease.

关 键 词：脂肪肝 肝硬化 高脂饮食 肝纤维化 相关关系 实验研究 

分 类 号：R575.5[医药卫生—消化系统] R575.2[医药卫生—内科学]