含精氨酰-甘氨酰-天冬氨酰序列短肽的合成及应用研究进展  

Research Progresses of the Synthesis and Application of Oligopeptide Containing Arg-Gly-Asp Sequence.

作　　者：左斌海[1] 付清泉[1] 李天全[1] 万昌秀[2] 

机构地区：[1]四川大学化工学院应用化学系,四川成都610065 [2]四川大学高分子材料系,四川成都610065

出　　处：《航天医学与医学工程》2002年第2期152-156,共5页Space Medicine & Medical Engineering

基　　金：国家自然科学基金资助 (2 98740 2 2 )

摘　　要：精氨酰 -甘氨酰 -天冬氨酸 (RGD)是具有生物活性的短肽序列之一。它是大多数细胞表面粘附分子能识别的配体上的最小氨基酸序列 ,在内皮细胞的识别、抗血栓、抑制肿瘤 ,治疗烧伤和皮肤溃疡等方面具有重要的作用。本文综述了近年来国内外对含RGD序列短肽的合成及其应用研究进展。Arg Gly Asp(RGD) is one of the oligopeptides with biological activity found in recent years. It is the minimum ammonia serial on the ligand, which can be recognized by most of the integrins. It has important influence on the recognition of endothelial cell ,anti thrombus and anti tumour function,and the therapy of burn and skin helcosis.In this review, the synthesis and application of oligepoptide containing RGD sequence were discussed.

关 键 词：精氨酰-甘氨酰-天冬氨酸 液相合成 固相合成 酶促合成 生物活性肽 研究进展 

分 类 号：Q516[生物学—生物化学]