晚期胰腺癌围手术期免疫调节治疗的疗效评价  

EFFECT OF IMMUNOREGULATORY THERAPY IN ADVANCED PANCREATIC CANCER PRE-AND-POST OPERATION

作　　者：彭俊平[1] 胡勇[1] 冯燮林[1] 赵京丽[1] 谢之荣[1] 刘光中[1] 

机构地区：[1]四川省肿瘤医院外科,四川成都610041

出　　处：《中国现代普通外科进展》1999年第1期44-45,共2页Chinese Journal of Current Advances in General Surgery

摘　　要：目的 探讨晚期胰腺癌围手术期免疫调节治疗效果.方法 43例晚期胰腺癌随机分为香菇多糖综合治疗组和对照组,动态观察术后T细胞亚群、NK细胞活性的变化,比较两组病人的生存期.结果 香菇多糖综合治疗组术后NK活性、CD_3、CD_4细胞数和CD_4/CD_8比值较对照组明显升高(P<0.05);术后平均生存期(14.9±8.5)月,明显高于对照组(7.7±3.5)月(P<0.001).结论 晚期胰腺癌患者围手术期免疫调节综合治疗,有助于改善机体细胞免疫功能和提高病人生存期.Objective: To study the clinical effect of multiple treatment with im-munopotentiator in patients with advanced pancreatic cancer pre-and-post operation Methods:43 patients were divided into two groups randomly, and were tested dynamically the peripheral blood T lymphocyte subsets and natural kill cells. 21 of which were treated with lentinan pre- and post-operation, and the survival time were compared to control group. Results: The activity in natural kill cells, CD3 and CD4 positive cells, and CD4:CD8 ratio was significantly higher in patients treated with immunopotentiator than in control group post-operation (p< 0. 05), and the mean survival was 14.9 ±8.5 months, higher than in control group (7.7 ± 3. 5months, P < 0.001). Conclusion : The treatment with immunopotentiator pre- and post-operation could enhance the immune function and improve the survival time in the patients with advanced pancreatic cancer.

关 键 词：胰腺肿瘤 免疫疗法 香菇多糖 晚期胰腺癌 手术疗法 疗效 

分 类 号：R735.9[医药卫生—肿瘤] R730.51[医药卫生—临床医学]