多巴胺D_3受体基因多态性与精神分裂症及其亚型的关联分析  

Association study of dopamine D_3 receptor gene with schizophrenia subtypes

作　　者：汤宜朗[1] 王玉凤[1] 蔡焯基[2] 周儒伦[1] 周朝凤[1] 

机构地区：[1]北京大学精神卫生研究所 [2]首都医科大学附属北京安定医院

出　　处：《中华精神科杂志》2002年第1期11-14,共4页Chinese Journal of Psychiatry

摘　　要：目的　探讨精神分裂症及其亚型与多巴胺D3 受体 (DRD3)基因Ser9Gly多态性之间的关联。方法　使用病例 对照的关联分析方法 ,对 5 2 8例中国汉族精神分裂症患者及 2 41名正常对照者DRD3的多态性进行检测 ,并进行关联分析。结果　精神分裂症患者Gly9Gly基因型及Gly9等位基因明显高于对照组 (患者组及对照组Gly9Gly基因分别为 8 5 %及 4 6 %,P =0 0 5 3;Gly9等位基因频率分别为 2 8 4 %及 2 3 0 %,P <0 0 5 ) ;且首次发病为阳性症状者与对照组之间的等位基因的差异也有显著性 (Gly9等位基因频率分别为 2 8 6 %及 2 3 0 %,P <0 0 5 ,OR =1 337,95 %CI =1 0 2 0～1 75 2 )。结论　DRD3基因Ser9Gly多态性与精神分裂症整体存在显著性关联 ,尤其是与首次发病以阳性症状为主者关系密切。Objective To explore the association of dopamine D 3 receptor (DRD3) gene Ser9Gly polymorphism with schizophrenia subtypes in Chinese Han population. Methods The case-control association study was used to analyze the association of polymorphism in the DRD3 gene exon I with 528 schizophrenics/241 psychiatrically irrelevant controls. Results There was significant difference in genotypic or allelic distributions of DRD3 Ser9Gly polymorphism between patients and controls (genotypic frequency of Gly9Gly was 8.5% in patients and 4.6% in controls, P=0.053; allelic frequency of Gly9 was 28.4% in patients and 23.6% in controls respectively,P<0.05),the allelic difference between the patients with dominantly positive symptoms at first episode and the controls was also statistically significant (Gly9:28.6% and 23.0% in patients and controls respectively, P<0.05, OR=1.337, 95%CI=1.020～1.752). Conclusions Ser9Gly polymorphism of DRD3 gene is significantly associated with schizophrenia, especially in those patients with dominantly positive symptoms at first onset.

关 键 词：精神分裂症 受体 多巴胺D3 多态现象 遗传学 病例 

分 类 号：R749.3[医药卫生—神经病学与精神病学]