中国布依族、苗族人群线粒体DNA Region V区的遗传多态性  

Polymorphism of mitochondrial DNA region V in Bouyei people and Miao people living in Guizhou province of China

作　　者：李永念[1] 左丽[1] 柯越海[2] 陈阿英[1] 舒莉萍[1] 任玮[1] 

机构地区：[1]贵阳医学院免疫学教研室,550004 [2]复旦大学遗传学研究所

出　　处：《中华医学遗传学杂志》2002年第2期138-140,共3页Chinese Journal of Medical Genetics

基　　金：国家人类基因组南方研究中心资助~~

摘　　要：目的　研究中国布依族、苗族人群线粒体 DNA Region V区的遗传多态性。方法　采用 PCR直接测序法对布依族 (96份 )及苗族人 (90份 )样本线粒体 DNA Region V区进行序列分析。结果　在布依族及苗族样本中只发现标准型和短型两种多态 ,短型多态 (即 9bp缺失 )频率在布依族、苗族人群中分别为31.1%和 33.3%。结论　中国布依族、苗族人群线粒体 DNA Region V区有相似的多态性 ,而与其他民族或人种有一定差异。Objective: To investigate the polymorphism of mitochondrial DNA region V in Bouyei people and Miao people living in Guizhou province of China. Methods: Polymerase chain reaction and direct sequencing were used in the study. Results: Only two kinds of polymorphism were found in Bouyei and Miao people. One was standard pattern, the other short pattern. And the frequencies of short pattern (9 bp deletion) in Bouyei and Miao people were 31.1% and 33.3% respectively. Conclusion: The polymorphisms of mitochondrial DNA region V in Bouyei people and Miao people living in Guizhou province of China are similar, but they are different from those in other people.

关 键 词：布依族 苗族 线粒体DNA 遗传多态性 

分 类 号：R394[医药卫生—医学遗传学]