阿苯达唑脂质体在小鼠体内的分布及其药物动力学研究  

TISSUE DISTRIBUTION AND PHARMACOKINETICS OF LIPOSOMAL ALBENDAZOLE IN MICE

作　　者：魏农农[1] 温浩[2] 陆彬[1] 

机构地区：[1]四川大学华西药学院,四川成都610041 [2]新疆医科大学包虫病研究所,新疆乌鲁木齐830054

出　　处：《华西药学杂志》2002年第2期95-97,共3页West China Journal of Pharmaceutical Sciences

摘　　要：目的　了解阿苯达唑脂质体在小鼠体内的分布与药动学特征。方法　以中和法制备阿苯达唑脂质体 ,用氚标记液体闪烁法监测脂质体在小鼠体内的药物动力学过程。结果　脂质体经ip后 ,药物主要分布在肝脏。结论　阿苯达唑脂质体可特异性地将药物靶向到肝脏 ,提高了药物的生物利用度 ,在治疗肝包虫病方面有积极的作用。OBJECTIVE We designed the loposomal albendazole(ABZ-L)as a targeting drug delivery system to change the ABZ'S distribution and to improve its bioavilibility.METHODS Using neutralized method to prepare ABZ-L,and to be measured by 3 H labeled radioisotope tracer for ABZ distribution.RESULTS The highest ABZ concentrations in liver after peritoneal injection ABZ-L.CONCLUSION Above the results convincingly supported ABZ-L strongly changed free albendazole in tissues distribution in mice.Targeting function was experimentally confirmed,that ABZ-L has significantly organ selection and high bioavalability,especially more convincingly advantages for potential of clinical application.

关 键 词：阿苯达唑 脂质体 药物动力学 研究 小鼠 分布 液体闪烁 抗寄生虫药 

分 类 号：R978.6[医药卫生—药品] R969.1[医药卫生—药学]