无毛小鼠同类系的建立  

Establishment of congenic strains of hairless mice

作　　者：章金涛[1] 康巧珍[1] 杜献堂[1] 杜春燕[1] 王纯耀[1] 祝庆蕃[1] 

机构地区：[1]河南省实验动物中心,郑州450052

出　　处：《郑州大学学报（医学版）》2002年第2期174-176,共3页Journal of Zhengzhou University(Medical Sciences)

基　　金：河南省自然科学基金资助项目 2 0 0 40 2 0 90 0 ;国家自然科学基金资助项目 3 9970 119

摘　　要：目的 :培育包含无毛基因的同类系小鼠新品系 ,明确无毛基因在不同遗传背景下的表达方式。方法 :将无毛基因通过杂交互交导入法分别导入 6 15、C57BL/6、BALB/c、DBA/2共 4种近交系。结果 :已完成 4代导入 ,杂交的第 1代、第 3代均表现有毛 ,第 2代、第 4代互交育出 6 15、C57BL/6、BALB/c、DBA/2共 4种无毛小鼠 ,其脱毛规律同豫医无毛小鼠。结论 :无毛基因可以在不同的遗传背景下表达。Aim:To breed the new congenic strains of hairless mice, and study the expression of hairless gene in different hereditary backgrounds. Methods:Hairless gene was transferred into 615,C 57 BL/6,BALB/c, and DBA/2 inbred strains by cross intercross, respectively. Results:The 4th generation breeding had been accomplished. The mice of all 1st and 3rd hybrid generations all had hair and the 4 kinds of 615,C 57 BL/6,BALB/c, DBA/2 hairless mice had been bred successfully by intercrossing in the 2nd and 4th generations, whose regularity of hair losing was the same as YuYi hairless mice. Conclusion:The hairless gene can be expressed in different hereditary backgrounds.

关 键 词：无毛小鼠 同类系 无毛基因 基因表达 遗传学 

分 类 号：R394－33[医药卫生—医学遗传学]