热解碳的氮离子注入处理及其血液相容性评价  

Nitrogen ion implantation of LTIC and hemocompatibility investigation

作　　者：李昌荣[1] 王向晖[1] 郑志宏[1] 林梓鑫[1] 俞柳江[1] 张峰[1] 柳襄怀[1] 陈安清[2] 蒋振斌[2] 

机构地区：[1]中国科学院上海冶金研究所离子束开放研究实验室,上海200050 [2]上海市中山医院,上海200032

出　　处：《功能材料与器件学报》2002年第1期63-68,共6页Journal of Functional Materials and Devices

基　　金：上海市科技发展基金(No.98JC14015);"973"项目基金的资助(No.G2000067207-2)

摘　　要：主要报导了热解碳的氮离子注入处理、等离子体浸没离子注入及其血液相容性。用卢瑟福背散射、X射线衍射和喇曼光谱法分析样品的成份及结构。测试了注入前后热解碳样品的血小板粘附性能,经过注入处理的样品表面粘附较少的血小板,而且较少团簇及变形,优于临床应用的热解碳。蛋白质竞争吸附实验结果表明热解碳经PIII处理后,表面会吸附较多的白蛋白、较少的纤维蛋白原,具有更好的抗凝血性能。Nitrogen ion implantation of LTI-Carbon and its hemocompatibility were investigated. The implanted energy was 30～160keV and dose of nitrogen ions was and 8×1016～6×1017 ions/cm2 respectively. The structure and composition of samples were analysed by Rutherford backscattering spectroscopy (RBS), X-ray diffraction (XRD) and Raman spectra. Platelet adhesions of LTI-carbon before and after implantation were also investigated.The results show that after nitrogen ion implantation, less platelets are adhered to the surface. Moreover, there are less conglomeration and transfiguration. PIII-treated surfaces adsorb more HSA, but less HFG than untreated LTI-carbon, which show that after PIII treatment the samples have better anticoagulation properties than LTI-carbon .

关 键 词：热解碳 离子注入 血液相容性 人工心脏瓣膜 

分 类 号：R318.11[医药卫生—生物医学工程]