盐酸洛美沙星葡萄糖注射液细菌内毒素检查法的应用  

Study on the Bacterial Endotoxin Test for Lomefloxacin Hydrochloride and Glucose Injection

作　　者：韩翠艳[1] 翟伟宇[1] 程国平[1] 

机构地区：[1]齐齐哈尔医学院附属第一医院药剂科,齐齐哈尔市161041

出　　处：《中国药房》2002年第5期299-300,共2页China Pharmacy

摘　　要：目的 :研究盐酸洛美沙星葡萄糖注射液的细菌内毒素检查方法。方法 :参照《中国药典》2000年版 (二部 )收载的细菌内毒素检查法及其指导原则进行干扰试验。结果 :盐酸洛美沙星葡萄糖注射液对鲎试剂的凝集反应有干扰作用 ,调节药液 pH值至6 8～7 2可消除干扰 ,用灵敏度为0 25EU/ml的鲎试剂可进行细菌内毒素检查。结论OBJECTIVE:To study the bacterial endotoxin test for lomefloxacin hydrochloride and glucose injection.METHODS:According to the assigned method and guiding principle for bacterial endotoxin test in CHINESE PHARMACOPOEIA 2000,the interference test was performed.RESULTS:Lomefloxacin and glucose injection could interfere with limulus test,however,the interference could be eliminated after adjusting the pH of injection to 6.8～7.0.The proper concentration of limulus test agent of bacterial endotoxin test was 0.25EU/ml.CONCLUSION:Bacterial endotoxin test can be used for quality control of lomefloxacin and glucose injection.

关 键 词：洛美沙星 注射液 鲎试剂 细菌内毒素 干扰试验 应用 

分 类 号：R927.1[医药卫生—药学]