乙醛脱氢酶2基因多态性和饮酒习惯与肝癌发生的关系研究  

Primary Hepatocellular Carcinoma(PHC) and Aldehyde Dehydrogenase-2 Genotypes in Alcoholics

作　　者：李苏平[1] 丁建华[1] 吴建中[1] 高长明[1] 周建农[1] 苏平[1] 刘燕婷[1] 臧宇[1] 周学富[2] 丁保国[2] 王如鸿 

机构地区：[1]江苏省肿瘤防治研究所流行病学研究室,江苏南京210009 [2]泰兴市卫生防疫站,江苏泰兴225400

出　　处：《肿瘤防治杂志》2002年第3期228-230,共3页China Journal of Cancer Prevention and Treatment

基　　金：江苏省 1999年社会发展基金重点资助 (BS990 2 6 1)

摘　　要：目的 :研究当地饮酒习惯与乙醛脱氢酶 2 (ALDH2 )基因的多态性对肝癌危险性的影响。方法 :在江苏泰兴市选择 1999年 9月 1日～ 2 0 0 0年 12月 31日新发肝癌病人 88例 ,按性别、年龄和居住地1∶1配对 ,进行流行病学调查研究 ,并应用PCR RFLP方法检测研究对象的ALDH2基因型。统计分析采用EpiInfo软件包。结果 :饮大量高度酒能显著增加ALDH2变异基因型携带者患肝癌的危险性 (OR=7 2 0 ,χ2 =6 6 5 ,P <0 0 1)。结论 :ALDH2基因多态性和饮酒习惯与肝癌的发生有关。Objective To study the relation between primary hepatocellular carcinoma(PHC) and Aldehyde dehydrogenase 2(ALDH2) genotypes in alcoholics.Methods A case control study including 88 cases of newly diagnosed PHC and 88 controls matched on sex, age and resident area was carried out,blood samples from all individuals were collected and detected ALDH2 genotypes by PCR RFLP.Results The results showed that large amount of alcohol consumption with ALDH2 variant genotypes(G/A+A/A) can significant increase risk for PHC (OR=7 20, χ 2=6 65, P <0 01).Conclusions Large amount of alcohol consumption with ALDH2 variant genotypes (G/A+A/A) is a high risk factor for PHC.

关 键 词：肝肿瘤 流行病学 氧化还原酶类 乙醛 饮酒 

分 类 号：R735.7[医药卫生—肿瘤]