药物分子与β-环糊精络合的光谱研究  

SPECTROSCOPIC STUDY ON THE INCLUSION OF DRUG MOLECULES WITH β-CYCLODEXTRIN

作　　者：郭俊[1] 王文韵[1] 

机构地区：[1]中国科学院长春应用化学研究所,长春130022

出　　处：《应用化学》1991年第4期80-82,共3页Chinese Journal of Applied Chemistry

摘　　要：环糊精能在水溶液中包络尺寸合宜的分子至其疏水性的环状腔体中,包络过程被用于增大有机分子的水溶性,用作酶的模拟,用于色谱学、荧光光度法和室温磷光法等。β-环糊精(β-CD)是最通用的一种,其内腔直径为0.7nm。The inclusion reactions of procaine, acetanilide and p-acetamidophenol with β-cyclodex-trin have been studied by means of absorption and fluorescence spectrometry and theirstability constants were calculated. Through inclusion, β-cyclodextrin enhances the fluores-cence emission of the drug molecules and, in particular, reduces the hydrolysis ofprocaine in aqueous solution.

关 键 词：药物分子 Β-环糊精 络合 光谱 

分 类 号：R914[医药卫生—药物化学]