乳酸菌降胆固醇作用研究现状  

The state of the art on the mechanisms of lactic acid bacteria in reducing chole sterol

作　　者：韩俊华[1] 盛晓甘 董彩凤[1] 葛春美[1] 张柏林[1] 

机构地区：[1]河北农业大学,河北保定071001 [2]甘肃好为尔生物科技股份有限公司,甘肃兰州730070

出　　处：《中国乳品工业》2002年第3期16-20,共5页China Dairy Industry

基　　金：国家教育部归国留学人员基金

摘　　要：乳酸菌及其相关制品具有降低介质以及血清中胆固醇的能力,已被体内及体外的大量实验所证实。然而,国内外对于乳酸菌降低胆固醇的作用机理尚存在不同的观点,主要体现在:①乳酸菌细胞直接吸收胆固醇;②乳酸菌的胆盐水解酶活性使胆盐由结合态转变为脱结合态,与胆固醇发生共同沉淀;③其他理论,如抑制胆固醇合成途径中的酶等。对涉及上述作用机理的相关研究作了评述,提出和分析了研究中所存在的问题。Ever-growing evidences in vivo and in vitro have shown that administ ration of lactic acid bacteria(LAB)preparations and related products are able to reduce serum cholesterol,offering potential benefits to hypercholesterol indivi duals.However,the three different mechanisms by which LAB induced the lowing of cholesterol have been established due to the diverse scientific reports from bot h at home and abroad.They are:1assimilation of cholesterol;2de-conjugation of b ile salts;3other mode of action like inhibiting the key enzymes required for bi osynthesis of cholesterol.Some problems associated with research into the decrea se of cholesterol by LAB were also considered.

关 键 词：乳酸菌 降胆固醇作用 研究现状 

分 类 号：TS252.1[轻工技术与工程—农产品加工及贮藏工程]