单纯疱疹病毒性角膜基质炎的鼠模型建立  

Construction of mice mode of herpes simplex keratitis

作　　者：张铁英[1] 杨秋霞[2] 齐艳华[1] 郗雪艳[2] 王辉[2] 谷静芝[1] 林辉[1] 高雅[1] 

机构地区：[1]哈尔滨医科大学第二临床医学院眼科 [2]哈尔滨医科大学免疫学教研室,黑龙江哈尔滨150086

出　　处：《哈尔滨医科大学学报》2002年第3期215-216,共2页Journal of Harbin Medical University

摘　　要：目的　建立单纯疱疹病毒性角膜基质炎 (HSK)的鼠模型 ,为研究HSK的发病机制及临床治疗奠定基础。方法　用HSV 1RE株感染Balb c鼠角膜 ,建立HSK的鼠模型 ,并在感染后 1天、3天、7天观察病变。结果　实验组鼠角膜有HSK病变发生 ,而空白对照组鼠角膜上皮愈合、完整光滑。结论　HSV 1RE株感染Balb c鼠有效 ,可致HSK发生。Objective To construct Balb/c mice model of herpes simplex keratitis(HSK) in order to make basis for the pathogensis of HSK and clinical treatmemts.Methods Corneas of Balb/c mice were infected by HSV 1 RE strain and monitored on 1,3,7d after infection by slit lamp.Results Corneas of treated mice developed HSK,while cornea epithelia of control mice were healed and smooth.Conclusion Infection of Balb/c mice with HSV 1 RE strain can lead to HSK.

关 键 词：单纯疱疹病毒性角膜基质炎 单纯疱疹病毒-1 角膜基质炎 动物模型 

分 类 号：R772.22[医药卫生—眼科] R－33[医药卫生—临床医学]