Inhibition Effects of Salvianolic Acid M and Rosmarinic Acid in Salvia deserta Schang on Human Aldose Reductase  

作　　者：Qian HE Jie WU Xinling WANG Jian YANG 

机构地区：[1]College of Pharmacy,Xinjiang Medical University,Urumqi 830011 [2]Affiliated Traditional Chinese Medical Hospital,Xinjiang Medical University,Urumqi 830011 [3]Xinjiang Technical Institute of Physics and Chemistry,State Key Laboratory Basis of Xinjiang Indigenous Medicinal Plants Resource Utilization,Chinese Academy of Sciences,Urumqi 830011,China

出　　处：《Asian Agricultural Research》2019年第8期69-70,共2页亚洲农业研究（英文）

基　　金：Supported by Scientific Research Plan for Colleges and Universities in Xinjiang Uygur Autonomous Region(XJEDU2018Y025)

摘　　要：[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase( AR). [Methods]The isolated salvianolic acid M and rosmarinic acid were prepared into different concentrations of solutions for in vitro enzyme kinetics experiments. [Results]Salvianolic acid M and rosmarinic acid had the strongest inhibition effects at the concentration of 1 g/L. [Conclusions]Salvianolic acid M and rosmarinic acid have inhibition effects on human aldose reductase. The IC50 of salvianolic acid M is 0. 79 μg/mL,and that of rosmarinic acid is 1. 13 μg/mL.[Objectives]This study aimed to investigate the inhibition effects of two chemical constituents in Salvia deserta Schang on human aldose reductase（ AR）. [Methods]The isolated salvianolic acid M and rosmarinic acid were prepared into different concentrations of solutions for in vitro enzyme kinetics experiments. [Results]Salvianolic acid M and rosmarinic acid had the strongest inhibition effects at the concentration of 1 g/L. [Conclusions]Salvianolic acid M and rosmarinic acid have inhibition effects on human aldose reductase. The IC50 of salvianolic acid M is 0. 79 μg/mL,and that of rosmarinic acid is 1. 13 μg/mL.

关 键 词：SALVIA deserta Schang ALDOSE REDUCTASE Salvianolic ACID M Rosmarinic ACID 

分 类 号：R285[医药卫生—中药学]