遗传性多发性骨软骨瘤病的全身骨扫描特点  

^(99m)Tc-MDP whole body bone imaging in patients with multiple osteochondroma

作　　者：张连娜[1] 冯瑾[1] 陈瑞玲[1] 何海燕[1] 杨芳[1] 

机构地区：[1]北京积水潭医院核医学科,北京100035

出　　处：《临床和实验医学杂志》2014年第13期1111-1114,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的分析遗传性多发性骨软骨瘤(HME)的99mTc-MDP全身骨显像的影像特点,评价骨显像在HME中的应用价值。方法分析74例确诊为HME患者的临床、骨显像资料,总结HME的骨显像特点。结果 74例患者中,肿瘤好发部位位于长骨的干骺端,颅面骨未见发现,主要表现为长骨干骺端骨质增粗,以膝关节周围表现最为明显;在所有病灶中,未见放射性摄取减低病灶(0级)。全身骨显像共显示371个病灶,其中1级摄取病灶占全部病灶的8.6%(32/371),2级摄取病灶占全部病灶的34.2%(127/371),3级摄取病灶占全部病灶的39.6%(147/371),4级摄取病灶占全部病灶的17.5%(65/371)。结论 HME的全身骨显像表现为长骨末端异常的、不规则的、多处的放射性浓聚,结合临床及其他影像学资料,99mTc-MDP全身骨显像可用于HME患者的诊断与鉴别诊断、随访以及肿瘤恶变的评价。Objective To investigate the usefulness of 99Tcm-MDP whole body bone scintigraphy（ WBBS） in patients with Hereditary multiple exostoses HME. Methods99mTc- MDP WBBS was performed in 74 patients with HME. The typical scintigraphic manifestations of Hereditary multiple exostoses HME were summarized. Results Bone scintigraphy found that the most common location of exostosis was juxta-epiphyscal regions of the long bones among 74 patients,showed bone thickening. The change around the knee joint was the most obvious. No exostosis was found in skull. In all lesions,1 grade of uptake accounted for8. 6% of all lesions（ 32 /371）,2 grade of uptake lesions accounted for 34.2 of all lesions（ 127 /371）,3 uptake lesions accounted for 39. 6% of all lesions（ 147 /371）,four pickup lesions account for all lesions of 17. 5%（ 65/371）. Conclusion Hereditary multiple exostoses showed irregular various radioactive concentration in end of long bones,99Tcm- MDP bone scintigraphy which combined with clinical and radiological data can be used to diagnose,differentiate,and localize the insidious lesion and evaluate the tumor malignant transformation in patients with HME.

关 键 词：遗传性多发性骨软骨瘤 全身骨显像 放射性核素 

分 类 号：R738.3[医药卫生—肿瘤]