Two terpenoids and a polyketide from the endophytic fungus Trichoderma sp. Xy24 isolated from mangrove plant Xylocarpus granatum  

红树林木果楝属植物内生真菌Trichoderma sp. Xy24的两个萜类和一个聚酮类化合物(英文)

作　　者：张敏[1,2] 李宁[1,2] 陈日道 邹建华[2] 王春梅[1] 戴均贵[1,2] 

机构地区：[1]北京中医药大学中药学院,北京100102 [2]中国医学科学院 北京协和医学院药物研究所 天然药物活性物质与功能国家重点实验室,北京100050

出　　处：《Journal of Chinese Pharmaceutical Sciences》2014年第6期421-424,共4页中国药学（英文版）

基　　金：Science&Technology Project of Guangdong Province(Grant No.2011A080403020);the Fundamental Research Funds for the Central Universities(Grant No.2012N06)

摘　　要：Three known compounds were isolated from the endophytic fungus Trichoderma sp Xy24 from a mangrove plant Xylocarpus granatum by using various column chromatography techniques. Their structures were identified as harzianone （1）, trichoacorenol （2）, and trichodimerol （3） by extensive spectroscopic analysis. Among them, 1 was a harziane diterpene, 2 was a sesquiterpene alcohol, and 3 was a polyketide with a completely symmetric configuration. Compound 3 exhibited medium inhibitory activity with an IC50 value of 74.6 μM using a NA （H7N9）/MUNANA model.从一株红树林木果楝属植物内生真菌Trichoderma sp.Xy24中分离得到3个化合物,包括一个Harziane二萜harzianone(1),一个菖蒲烷型倍半萜醇trichoacorenol(2)以及一个具有完全对称结构的聚酮类化合物trichodimerol(3)。其化学结构通过旋光、质谱以及核磁共振波谱等波谱方法确定。化合物3具有中等程度的抗病毒活性。

关 键 词：Endophytic fungus Trichoderma sp. Xy24 TERPENOID POLYKETIDE Xylocarpus granatum 

分 类 号：R284[医药卫生—中药学]