P53和CD44v6在食管鳞癌中的表达及其临床病理意义  

Clinicopathological Significance of P53 and CD44v6 Expression in Esophageal Squamous Cell Carcinoma

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作  者:高洁[1] 刘弯 曹丹[3] 郜慧英[1] 

机构地区:[1]菏泽医学专科学校,山东菏泽274000 [2]定陶县人民医院重症监护科 [3]附属菏泽市立医院妇产科

出  处:《菏泽医学专科学校学报》2014年第3期4-6,43,共4页Journal of Heze Medical College

摘  要:目的探讨P53和CD44v6在食管鳞状细胞癌中的表达及与临床病理参数之间的关联性,并分析其与肿瘤浸润转移的关系。方法制作组织芯片并应用免疫组织化学PV-9000二步法检测52例食管鳞状细胞癌组织和18例食管炎症炎组织中P53及CD44v6的表达,采用SPSS19.0统计软件分析各临床病理参数之间的关系,并探讨P53和CD44v6之间的关联性。结果 P53和CD44v6在食管鳞癌中的表达高于在食管炎组中的表达(P<0.05),且在伴有淋巴结转移的鳞癌病例中的阳性率远高于其在无淋巴结转移组中的阳性率(P<0.05);P53和CD44v6在食管鳞状细胞癌中的表达无明显相关性(r=0.202,P>0.05)。结论 P53和CD44v6在食管鳞状细胞癌中表达明显上调,其高表达预示转移性大及预后较差。Objective To investigate the correlation between the expression of P53 and CD44v6 in esophageal squa- mous cell carcinoma and clinicopathological parameters, and to analyze its relationship with tumor invasion and metastasis. Methods Making tissue microarray and using immunohistochemical PV-9000 two step method to detect 52 cases of esophageal squamous cell carcinoma tissues and 18 cases of esophageal inflammation of tissues, analyze the relationship between the clinical and pathological parameters using SPSS19.0 statistical software, and to explore the correlation between P53 and CD44v6. Results The expression of P53 and CD44v6 in esophageal squamous cell carcinoma was higher than that in esophagitis in the group (P〈 0.05), and in patients with lymph node positive rate of metastasis of squamous cell carci- noma cases is much higher than in the no lymph node metastasis group (P〈0.05); There is no significant correlation between the expression of P53 and CD44v6 in the esophageal squamous cell carcinoma (r=0.202, P〉0.05). Conclusion P53 and CD44v6 expression are significantly increased in esophageal squamous cell carcinoma, which suggests that high expression of metastasis and poor prognosis.

关 键 词:P53 CD44V6 食管鳞癌 组织芯片 

分 类 号:R735.1[医药卫生—肿瘤] R392.3[医药卫生—临床医学]

 

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