ACE2/Ang-(1-7) signaling and vascular remodeling  

作　　者：ZHANG ZhenZhou CHEN LaiJiang ZHONG JiuChang GAO PingJin OUDIT Gavin Y. 

机构地区：[1]State Key Laboratory of Medical Genomics,Ruijin Hospital Affiliated to Shanghai Jiao Tong University School of Medicine [2]Shanghai Key Laboratory of Hypertension,Shanghai Institute of Hypertension [3]Department of Medicine,University of Alberta [4]Mazankowski Alberta Heart Institute

出　　处：《Science China(Life Sciences)》2014年第8期802-808,共7页中国科学（生命科学英文版）

基　　金：supported by Training Program of the National Major Research Plan(91339108);General Program(81370362,81170246)of the National Natural Science Foundation of China;the National Basic Research Program of China(2014CB542300)

摘　　要：The renin-angiotensin system(RAS)regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS has led to important pharmacological tools to prevent and treat vascular diseases such as hypertension,diabetic vasculopathy and atherosclerosis.Angiotensin converting enzyme 2(ACE2)was recently identified as a multifunctional monocarboxypeptidase responsible for the conversion of angiotensin(Ang)II to Ang-(1-7).The ACE2/Ang-(1-7)signaling has been shown to prevent cellular proliferation,pathological hypertrophy,oxidative stress and vascular fibrosis.Thus,the ACE2/Ang-(1-7)signaling is deemed to be beneficial to the cardiovascular system as a negative regulator of the RAS.The addition of the ACE2/Ang-(1-7)signaling to the complexities of the RAS may lead to the development of novel therapeutics for the treatment of hypertension and other vascular diseases.The present review considers recent findings regarding the ACE2/Ang-(1-7)signaling and focuses on its regulatory roles in processes related to proliferation,inflammation,vascular fibrosis and remodeling,providing proof of principle for the potential use of ACE2 as a novel therapy for vascular disorders related to vascular remodeling.The renin-angiotensin system（RAS）regulates vascular tone and plays a critical role in vascular remodeling,which is the result of a complex interplay of alterations in vascular tone and structure.Inhibition of the RAS has led to important pharmacological tools to prevent and treat vascular diseases such as hypertension,diabetic vasculopathy and atherosclerosis.Angiotensin converting enzyme 2（ACE2）was recently identified as a multifunctional monocarboxypeptidase responsible for the conversion of angiotensin（Ang）II to Ang-（1-7）.The ACE2/Ang-（1-7）signaling has been shown to prevent cellular proliferation,pathological hypertrophy,oxidative stress and vascular fibrosis.Thus,the ACE2/Ang-（1-7）signaling is deemed to be beneficial to the cardiovascular system as a negative regulator of the RAS.The addition of the ACE2/Ang-（1-7）signaling to the complexities of the RAS may lead to the development of novel therapeutics for the treatment of hypertension and other vascular diseases.The present review considers recent findings regarding the ACE2/Ang-（1-7）signaling and focuses on its regulatory roles in processes related to proliferation,inflammation,vascular fibrosis and remodeling,providing proof of principle for the potential use of ACE2 as a novel therapy for vascular disorders related to vascular remodeling.

关 键 词：angiotensin converting enzyme 2 INFLAMMATION vascular remodeling angiotensin II oxidative stress 

分 类 号：R363[医药卫生—病理学]