HuR and post-transcriptional regulation in vascular aging  

作　　者：WANG WenGong 

机构地区：[1]Research Center on Aging,Department of Biochemistry and Molecular Biology,Peking University Health Science Center

出　　处：《Science China(Life Sciences)》2014年第8期863-866,共4页中国科学（生命科学英文版）

基　　金：supported by the National Natural Science Foundation of China(81230008,91339114);111 project of Ministry of Education of China(B07001)

摘　　要：HuR(ELAV11(embryonic lethal,abnormal vision)-like 1),a ubiquitously expressed member of the ELAV-like RNA-binding protein family,has been shown to regulate the stability and translation of mRNAs that encode factors regulating cellular senescence,thereby impacting on aging.In this review,we discuss the current knowledge of HuR’s role in vascular cell senescence and vascular aging.HuR（ELAV11（embryonic lethal,abnormal vision）-like 1）,a ubiquitously expressed member of the ELAV-like RNA-binding protein family,has been shown to regulate the stability and translation of mRNAs that encode factors regulating cellular senescence,thereby impacting on aging.In this review,we discuss the current knowledge of HuR’s role in vascular cell senescence and vascular aging.

关 键 词：HUR mRNA turnover TRANSLATION cell senescence vascular aging 

分 类 号：R543[医药卫生—心血管疾病]