产热型脂肪分化调控机制研究进展  

Advances in Molecular Mechanisms Responsible for Formation of Thermogenic Fat

作　　者：马翊鹏 杨芝春[1] 

机构地区：[1]中南大学药学院药理学系,湖南省长沙市410008

出　　处：《中国动脉硬化杂志》2014年第8期859-864,共6页Chinese Journal of Arteriosclerosis

基　　金：国家自然科学青年基金资助项目(81001464)

摘　　要：脂肪组织是调节人体能量代谢的重要器官。储能型脂肪(白色脂肪)过量积累可导致肥胖,引发健康问题,而产热型脂肪(棕色/米色脂肪)通过线粒体的氧化产热消耗能量,具有潜在的抗肥胖作用。研究显示产热型脂肪可由众多前体细胞分化而来,其分化方向受多种转录因子包括PRDM16、PPARγ、SIRT1等调控,且这些转录因子参与了动脉粥样硬化的发生。本文就调控产热型脂肪分化形成的分子机制综述如下。Adipose tissue is an important metabolic organ involved in energy balance. Excess accumulation of white adipose tissue（ also called energy storage fat） leads to obesity,atherosclerosis and other health problems. Thermogenic fat（ including brown and beige adipose tissue） has the potential to anti-obesity by thermogenic effects which can consume calories. Documents demonstrate that brown /beige adipocytes are originated from multiple precursor cells. The present review is mainly focused on the regulatory molecular mechanisms for the formation of thermogenic fat including PRDM16,PPARγ,SIRT1 and other factors.

关 键 词：产热型脂肪 棕色脂肪 米色脂肪 动脉粥样硬化 PRDM16 PPARΓ SIRT1 

分 类 号：R363[医药卫生—病理学]