长期住院精神分裂症患者认知功能相关研究  

Cognitive Function of Long-term Schizophrenia

作　　者：彭焱[1] 李薇[2] 杜君[1] 王健[3] 邹义壮[3] 谭淑平[3] 张进国[3] 陈楠[3] 范宏振[3] 崔介峰[3] 

机构地区：[1]中国.河北联合大学心理学院,唐山063000 [2]河北联合大学出版管理中心 [3]北京回龙观医院,100096

出　　处：《中国健康心理学杂志》2014年第9期1301-1303,共3页China Journal of Health Psychology

基　　金：唐山市科技计划项目课题(编号:12150222B-10)

摘　　要：目的：探讨长期住院精神分裂症患者认知功能情况，其性别、年龄、病程是否存在差异。方法对41例长期住院精神分裂症患者进行认知功能成套测验（ MCCB ）测评，并选取在性别、年龄、受教育程度等方面均与之相匹配的正常人做对照。结果①患者与正常对照相比，连线测验、符号编码、言语记忆、迷宫、情绪管理以及MCCB总分均存在显著性差异（ t＝-2．09，P＝0．040；t＝-3．54，P＝0．001；t＝-3．10，P＝0．003；t＝-3．39，P＝0．001；t＝-2．60，P＝-0．011；t＝-2．50，P＝0．015），患者分数均比正常对照低；②患者男性与女性MCCB不存在显著性差异（P＞0．05）；③患者年龄分组比较，其中41～49岁组的言语记忆、迷宫、视觉记忆分数以及总分均显著高于≥50岁组（ t＝2．31，P＝0．031；t＝2．66，P＝0．012；t ＝1．99，P＝0．047；t＝2．29，P＝0．028）；并且该组言语记忆测验分数也显著高于≤40岁组（ t＝-2．35， P＝0．029）；④患者病程分组比较，其中病程≤15年组的符号编码、视觉记忆、情绪管理能力分数以及总分均明显低于病程≥25年组（t＝-2．27，P＝0．035；t ＝-2．44，P＝0．024；t＝-2．57，P＝0．018；t＝-2．04，P＝0．050）；病程≤15年组的符号编码、MCCB总分均明显低于病程15～24年组（t ＝-2．26，P＝0．037；t＝-2．26，P＝0．035）。结论长期住院精神分裂症患者存在认知功能损害，其认知功能损害无明显性别差异，但在年龄及病程方面有差异。Objective To investigate the cognitive function of long -term schizophrenia .Methods 41 people with long -term schizophrenia were measured by The MATRICS Consensus Cognitive Battery （MCCB）.The controls,including 40 health people matched to the patient in gender,age and education.Results ①TMT,SC,HVLT-R,NAB -MAZES,MSCEIT -ME and MCCB composite scores were significantly different between patients and normal controls （t =-2.09,P=0.040;t =-3.54,P=0.001;t =-3.10,P =0.003;t=-3.39,P=0.001;t=-2.60,P=-0.011;t=-2.50,P=0.015）,The patients＇scores were lower than the normal controls＇.②MCCB had no significant difference between male and female of patients .③HVLT-R,BVMT-R,NAB-MAZES and MCCB composite scores in the group of 41～49 age were significantly higher than those in the group of ≥50 age（ t=2.31,P=0.031;t=2.66,P=0.012;t=1.99,P=0.047;t=2.29,P=0.028）.HVLT-R score in the group of 41～49 age was significantly higher than that in the group of ≤40 age（t=-2.35,P=0.029）.④SC,BVMT-R,MSCEIT-ME and MCCB composite scores in the group of course ≤15 years were significantly lower than those in the group of course ≥25 years（t=-2.27,P=0.035;t=-2.44,P=0.024;t=-2.57,P=0.018;t=-2.04,P=0.050）.SC and MCCB composite scores in the group of course ≤15 years were significantly lower than those in the group of course 15-24 years（t=-2.27,P=0.035;t=-2.44,P=0.024;t=-2.57,P=0.018;t=-2.04,P=0.050）.Conclusion Long-term schizophrenia has cognitive function impairment ,which has no significant gender differences and significant differences in age and course .

关 键 词：精神病学 长期住院患者 精神分裂症认知功能成套测验( MCCB) 认知功能 

分 类 号：R749.3[医药卫生—神经病学与精神病学]