mTOR在HER-2阴性乳腺癌中的表达及意义  

Expression and significance of mTOR in Her-2 negative breast cancer

作　　者：王立波[1] 王彦荣[1] 席妍[1] 李晓萌[2] 

机构地区：[1]吉林省肿瘤医院内二科,吉林长春130012 [2]吉林大学中日联谊医院内镜中心

出　　处：《中国实验诊断学》2014年第8期1262-1264,共3页Chinese Journal of Laboratory Diagnosis

基　　金：吉林省自然科学基金项目(项目编号201015233)

摘　　要：目的观察mTOR蛋白在Her-2阴性乳腺癌中的表达,探讨其与Her-2阴性乳腺癌发生发展相关性,为Her-2阴性乳腺癌寻找新的治疗靶点。方法采用免疫组织化学技术检测65例Her-2阴性乳腺癌、癌旁组织及正常乳腺组织中mTOR的表达情况。结果 Her-2阴性乳腺癌组织中mTOR蛋白表达明显高于癌旁组织及正常乳腺组织,差异有统计学意义(P<0.05)。mTOR阳性表达在腋窝淋巴结阳性组明显高于淋巴结阴性组,差异有统计学意义(P<0.05)。结论 mTOR可能与Her-2阴性乳腺癌发生与发展相关,与腋窝淋巴结转移相关,可作为Her-2阴性乳腺癌的预后指标及新的治疗靶点。Objective We examined the expression of mTOR protein in Her-2negative breast cancer.Discussits clinical significance and looks for new therapeutic target for Her-2negative breast cancer.Methods mTOR were determined immunohistochemically in 65 cases of Her-2 negative breast cancer,tumor-adjacent tissues and normal tissues.Results Positive mTOR expression was noted in Her-2negative breast cancer apparently higher than tumor-adjacent tissues and normal tissues（P〈0.05）.it was also obviously higher in group with axillary lymphnode metastasis than in group with out lymphnode metastasis（P〈0.05）.Conclusion Expression of mTOR？significantly increased in Her-2negative breast cancer.The detection of mTOR play an important role in tumorigenesi,it has significant correlation with axillary lymphnode metastasiss,and provide a new road for trentment of Her-2 negative breast cancer.

关 键 词：MTOR Her-2阴性 乳腺肿瘤 

分 类 号：R737.9[医药卫生—肿瘤]