潍坊地区孕中期唐氏综合征筛查血清标志物中位数值的建立  

Establishment of medians of maternal serum markers for Down's syndrome screening during the second trimester of pregnancy in Weifang city

作　　者：王瑞丽[1] 王成东[1] 于桂玉 

机构地区：[1]山东省潍坊市人民医院产前诊断科,261041 [2]山东省潍坊市坊子区人民医院妇产科

出　　处：《中国妇幼保健》2014年第25期4146-4148,共3页Maternal and Child Health Care of China

摘　　要：目的：建立潍坊地区正常孕妇产前筛查唐氏综合征血清学标志物甲胎蛋白（AFP）、游离人绒毛膜促性腺激素（F-β-hCG）的中位数据库。方法：应用时间分辨荧光检测技术,对13 827例15-20周的孕妇血清进行AFP、F-β-hCG含量的测定,排除各种异常病例,将剩余的13 399例正常孕妇进行统计学分析,2T-risk进行风险评估。结果：建立了潍坊地区正常孕妇15-20周产前筛查血清学标志物AFP、F-β-hCG的中位数据库,实验数据分别与软件内嵌值及温州地区相应数据比较：AFP中位浓度与软件内嵌相应数据比较差异无统计学意义（PAFP〉0.05）,与温州地区比较差异有统计学意义（PAFP〈0.05）;F-β-hCG中位浓度与软件内嵌数据比较差异有统计学意义（PhCG〈0.05）;与温州地区比较差异无统计学意义（PhCG〉0.05）。利用本地区的中位数据库将13 399例孕妇重新进行风险评估,唐氏综合征检出率和假阴性率不变的前提下,潍坊地区的产前筛查的阳性率及假阳性率降低了。结论：各地区应尽快建立自己的中位数值数据库。Objective： To establish the median databases of serum markers - alpha fetoprotein （AFP） and free - β- human chorionic gonadotropin （F- β-hCG） during prenatal screening of Dowries syndrome among normal pregnant women in Weifang city Methods： Time- resolved fluorometry was used to detect the serum contents of AFP and F- β-hCG in 13 827 pregnant women during 15 -20 gestational weeks; the abnormal patients were excluded, the residual 13 399 normal pregnant women were analyzed statistically, risk evaluation was conducted by 2T- risk. Results： The median databases of serum markers （AFP and F- β -hCG） were established among normal pregnant women during 15 -20 gestational weeks in Weifang city, the experimental data were compared with software embedded value and corresponding data in Wenzhou city, there was no statistically significant difference in the median concentration of AFP between the study and software embedded value （ PAFP〉0. 05 ） , while compared with Wenzhou city, there was statistically significant difference （ PAFP 〈 0. 05 ） ; there was statistically significant difference in the median concentration of F - β- hCG between the study and software embedded value （PhCG 〈 0. 05） , while compared with Wenzhou city, there was no statistically significant difference （ PhCG 〉 0. 05 ） ; risk evaluation was conducted again among 13 399 pregnant women in Weifang city based on the median database in the area, on the premise of maintaining the detection rate and false negative rate of Downg syndrome unchanged, the positive rate and false positive rate of prenatal screening in Weifang city decreased. Conclusion： It is suggested that median databases should be set up as soon as possible in different regions.

关 键 词：血清学指标 唐氏综合征 产前筛查 中位数 甲胎蛋白 游离人绒毛膜促性腺激素 

分 类 号：R715.5[医药卫生—妇产科学]