云南省育龄人群红细胞叶酸水平与出生缺陷的关联研究  

Study on the correlation between folic acid level in red blood cells and birth defects in population of childbearing age in Yunnan province

作　　者：张杰[1] 刘立芳[1,2] 苏洁[1] 陈红[1] 朱姝[1] 章锦曼[1] 陈姝[1] 银益飞[1] 黎冬梅[1] 朱宝生[1] 

机构地区：[1]云南省第一人民医院遗传诊断中心云南省出生缺陷与遗传病研究重点实验室,云南昆明650032 [2]昆明理工大学信息工程与自动化学院生物医学工程研究所

出　　处：《中国妇幼保健》2014年第26期4218-4220,共3页Maternal and Child Health Care of China

基　　金：云南省科技计划项目专项资金资助〔2011CA017〕

摘　　要：目的：通过检测有不良孕产史育龄人群的红细胞叶酸与正常人群红细胞叶酸水平,了解叶酸缺乏和不良孕产史之间的关系。方法：2013年1月-2013年12月收集到云南省第一人民医院遗传诊断中心进行孕前咨询有过不良孕产史育龄人群,检测两组人群与正常人群的叶酸水平,对出生缺陷的相关因素进行统计分析,评估叶酸对于不良妊娠的影响。结果：通过对正常人群组2 639例与不良生育史246例患者的分析,正常人群组与脑部异常儿生育史患者的叶酸水平比较,差异有统计学意义（P〈0.05）,正常人群组与胎儿畸形、自然流产和胎停育、神经管缺陷引产史、唐氏综合征生育史、其他染色体异常生育史组间叶酸水平比较,无统计学差异（P〉0.05）。结论：增补叶酸对预防出生缺陷有一定意义,育龄人群应适时增补叶酸。Objective： To understand the relationship between folie acid deficiency and adverse pregnancy history by detecting the levels of folic acid in red blood cells in population of childbearing age with adverse pregnancy history and normal population. Methods： The population of childbearing age with adverse pregnancy history who went to genetic diagnosis center of the hospital from January 2013 to November 2013 for preconception counseling were collected; the levels of folic acid in population of childbearing age with adverse pregnancy history （246 cases） and normal population （2 639 cases） were detected, the relevant factors of birth defects were analyzed statistically, the effect of folic acid on adverse pregnancy was evaluated. Results： There was statistically significant difference in the level of folic acid be- tween normal population and the patients with birth history of brain abnormality infants （ P 〈 0. 05 ） ; there was no statistically significant difference in the level of folic acid between normal population and the patients with history of fetal malformations, spontaneous abortion, embryo damage, induced abortion because of neural tube defects and birth history of Downg syndrome and other chromosomal abnormalities infants （P 〉 0. 05） . Conclusion： Folic acid supplementation has a certain significance for preventing birth defects, which should be conducted among population of childbearing age in good time.

关 键 词：出生缺陷 叶酸 云南省 唐氏综合征 

分 类 号：R715.3[医药卫生—妇产科学]