Effects of naringin, a flavanone glycoside in grapefruits and citrus fruits, on the nigrostriatal dopaminergic projection in the adult brain  

作　　者：Un Ju Jung Sang Ryong Kim 

机构地区：[1]Center for Food and Nutritional Genomics Research, Kyungpook National University [2]School of Life Sciences, Kyungpook National University [3]BK21 plus KNU Creative BioResearch Group, Kyungpook National University [4]Institute of Life Science & Biotechnology, Kyungpook National University [5]Brain Science and Engineering Institute, Kyungpook National University

出　　处：《Neural Regeneration Research》2014年第16期1514-1517,共4页中国神经再生研究（英文版）

基　　金：supported by the National Research Foundation of Korea(NRF)grant funded by the Korea government,No.2008-0061888 and 2012R1A1A1039140

摘　　要：Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruits, to prevent neurodegeneration in a neurotoxin model of Parkinson＇s disease. Intraperitoneal injection of naringin protected the nigrostriatal dopaminergic projection by increasing glial cell line-derived neurotrophic factor expression and decreasing the level of tumor necrosis factor-alpha in dopaminergic neurons and microglia, respectively. These results suggest that naringin can impart to the adult dopaminergic neurons the ability to produce glial cell line-derived neurotrophic factor against Parkinson＇s disease with anti-inflammatory effects. Based on these results, we would like to describe an important perspective on its possibility as a therapeutic agent for Parkinson＇s disease.Recently, we have demonstrated the ability of naringin, a well-known flavanone glycoside of grapefruits and citrus fruits, to prevent neurodegeneration in a neurotoxin model of Parkinson＇s disease. Intraperitoneal injection of naringin protected the nigrostriatal dopaminergic projection by increasing glial cell line-derived neurotrophic factor expression and decreasing the level of tumor necrosis factor-alpha in dopaminergic neurons and microglia, respectively. These results suggest that naringin can impart to the adult dopaminergic neurons the ability to produce glial cell line-derived neurotrophic factor against Parkinson＇s disease with anti-inflammatory effects. Based on these results, we would like to describe an important perspective on its possibility as a therapeutic agent for Parkinson＇s disease.

关 键 词：NARINGIN parkinson＇s disease GDNF inflammation mTORCI NEURODEGENERATION 

分 类 号：R742.5[医药卫生—神经病学与精神病学]