5450例云南省育龄人群地中海贫血筛查结果分析  

Analysis of screening of thalassemia for 5450 adults in reproductive age in Yunnan province,China

作　　者：丁雪梅[1] 曾小红[1] 朱宝生[1] 张杰[1] 贺静[1] 苏洁[1] 章锦曼[1] 陈红[1] 李苏云[1] 章印红[1] 冯燕[1] 

机构地区：[1]昆明医科大学附属昆华医院遗传诊断中心,云南省出生缺陷与遗传病研究重点实验室,昆明650032

出　　处：《临床检验杂志》2014年第9期693-696,共4页Chinese Journal of Clinical Laboratory Science

基　　金：国家自然科学基金(81260415);云南省科技厅-昆明医学院联合专项重点项目(2011FB164)

摘　　要：目的调查云南省育龄人群地中海贫血(地贫)患病率。方法对孕前咨询的育龄夫妇和产前诊断孕妇进行Hb电泳和血常规检测,将Hb电泳阳性和(或)血常规指标阳性定义为筛查阳性,根据检测结果进行统计学分析。结果在5 450例完成筛查的受检者中,筛查出地贫携带者或患者570例(10.5%)。地贫筛查阳性率较高的民族依次为傣族(29.0%)、傈僳族(26.7%)、壮族(25.0%)、回族(13.4%);筛查阳性率较高的地区依次为德宏州(25.0%)、西双版纳州(21.7%)和文山州(20.1%)。结论云南省育龄人群地贫患病率较高,用血常规联合Hb电泳技术进行地贫筛查,可以有效地筛查出地贫。Objective To investigate the prevalence rate of thalassemia carriers in the adults at reproductive age in Yunnan province,southwest of China. Methods A total of 5 450 subjects including the couple of the preconception counselling and pregnant woman accepted prenatal diagnosis were examined by Hb electrophoresis and routine hematological test. The positive results of Hb electrophoresis and / or routine hematological test suggested thalassemia carriers or patients. All the data were statistically analyzed. Result Among the 5 450 subjects,570 cases were suspected as thalassemia carriers or patients（ 10. 5%）. The highest positive rates of thalassemia in different ethnic groups was Dai（ 29. 0%）,followed by Lisu（ 26. 7%）,Zhuang（ 25. 0%） and Hui（ 13. 4%）. The region with highest positive rate was Dehong Prefecture（ 25. 0%）,followed by Xishuangbanna（ 21. 7%） and Wenshan（ 20. 1%）. Conclusion High prevalence rate of thalassemia was demonstrated in Yunnan. Combination of the routine hematological test and the hemoglobin electrophoresis may be the available method for screening of thalassemia carriers.

关 键 词：地中海贫血 Hb电泳 血常规检查 育龄人群 云南省 

分 类 号：R446[医药卫生—诊断学]