饮用奶粉对青年女性月经周期和尿中激素排泄水平的影响  

Effects of daily consumption of milk powder on menstrual cycles and urine sex hormone concentrations of young women

作　　者：张曼[1] 朱婧[2] 汪之顼[1] 武洁姝[1] 耿珊珊[1] 范萍[1] 刘静[2] 杨月欣[3] 

机构地区：[1]南京医科大学公共卫生学院儿少卫生和妇幼保健学系,南京211166 [2]北京市营养源研究所 [3]中国疾病预防控制中心

出　　处：《卫生研究》2014年第5期754-758,共5页Journal of Hygiene Research

基　　金：圣元营养健康科研基金项目(No.2011-02);江苏高校优势学科建设工程资助项目

摘　　要：目的观察长期持续饮用奶粉对健康育龄妇女生理周期、排卵时机以及晨尿中性激素排泄水平的影响。方法招募32名健康青年女性并随机分配到两个组,分别给予不同的饮奶量,进行为期3个月经周期的饮奶实验。第一个月经周期为对照周期,第二个月经周期为饮奶周期。受试者从第二个月经周期月经来潮第4d开始每日饮奶,每日一次饮用33g(低剂量组)或55g(高剂量组)市售奶粉冲调的复原奶,持续21 d;第三个月经周期为停止饮奶的对照周期。在全部三个月经周期内,记录受试者周期长度,采用基础体温和排卵试纸测定排卵日期,多时点(第一、三月经周期第4、7、10、13、16、19和24 d,第二月经周期第4、5、6、7、9、12、15、18、21和24 d)采集晨尿样本,测定尿雌二醇、孕二醇以及肌酐浓度;将尿激素浓度随时间描绘曲线,计算至24d时的曲线下面积。结果高剂量组的三个月经周期分别平均为(29.60±3.180)、(28.87±3.021)和(29.60±2.995)d,低剂量组分别为(30.40±4.014)、(29.67±3.266)和(29.47±3.021)d,两个组的三个月经周期差异均无统计学意义,每个周期两组间差异也无统计学意义。高剂量组排卵日时间分别平均为(15.47±2.295)、(15.40±1.882)和(15.73±2.404)d,低剂量组排卵日时间为(16.93±1.624)、(15.73±2.344)和(15.47±2.200)d,两组的三个周期间差异无统计学意义,每个周期两组间差异无统计学意义。分别将第一、三周期的周期长度、排卵日时间与第二周期进行比较,其差值在两个组间差异无统计学意义。高剂量组三个周期内肌酐校正的尿雌二醇的曲线下面积分别为(7160.28±2305.52)、(6700.26±2066.67)和(6676.24±2573.89);低剂量组为(6838.21±1447.25)、(6611.33±1648.21)和(5949.24±1437.54)。高剂量组三个周期内肌酐校正的尿孕二醇的曲线下面积分别为(51.93±18.80)、(44.55±14.62)和(46.49±22.44);低剂量组为(49.25±15.68)、(48.79±15.61)�Objective To observe the effects of daily consumption of milk powder on healthy young women, including the effect on menstrual cycles, ovulation time and sex hormone concentrations in morning urine. Method Thirty-two young women were recruited as subjects and randomly assigned into two groups for a milk powder consumption experiment which lasted three menstrual cycles. The first menstrual cycle is control cycle, the second menstrual cycle is the milk-taking cycle. The subjects take milk diluted by 33g or 55g milk powder each day, from the 4th to the 24th day of the second menstrual cycle. The third menstrual cycle is control cycle after milk-taking. During the whole three menstrual cycles, record the length of each menstrual cycle, determine ovulation time by using basal body temperature and oviposit test paper, collect their morning urine samples at specified times（the 4 th , 7 th, 10 th, 13 rd, 16 th, 19 th and 24 th day of the first and the third menstrual cycle; the 4 th, 5 th, 6 th, 7 th, 9 th, 12 nd, 15 th, 18 th, 21 st and 24 th day of the second menstrual cycle）, determine the concentrations of estradiol, pregnanediol and creatinine in morning urine samples; draw the curve of the concentration changing over time and calculate the area under the curve to the 24th day. Result In the high-dose group, the mean of the menstrual cycle length are （29.60 ±3. 180） d, （28.87 ±3. 021） d, （29.60 ± 2. 995） d, the mean of the ovulation time are （15.47 ± 2. 295） d, （15.40±1.882） d, （15.73 ±2.404） d. In the low-dose group, the mean of the menstrual cycle length are （30.40 ± 4. 014） d, （29.67 ± 3. 266） d, （29.47 ± 3. 021 ） d,the mean of the ovulation time are （16.93 ± 1. 624） d, （15.73 ±2. 344） d, （15.47 ± 2. 200） d. There was no significant difference in menstrual cycle length and ovulation time among cycles and between groups （P 〉 0.05 ）. Calculate the difference between the first and the second menstrual cycle, and the difference between the third a

关 键 词：奶粉 外源性雌激素 女性生理周期 雌二醇 孕二醇 

分 类 号：R153.1[医药卫生—营养与食品卫生学] TS252.51[医药卫生—公共卫生与预防医学]