不同认知功能孤独症谱系障碍儿童在PEP-3中的反应特征  

Developmental profile of children with autism spectrum disorder on PEP-3

作　　者：彭仰华 静进[1] 叶晓芳[1] 黄哲兰[1] 陈学彬[1] 

机构地区：[1]中山大学公共卫生学院妇幼卫生学系,广东广州510080

出　　处：《中国儿童保健杂志》2014年第4期358-360,402,共4页Chinese Journal of Child Health Care

基　　金：国家自然科学基金(81172687);教育部博士点基金(20110171110053)

摘　　要：目的探索不同认知功能孤独症谱系障碍（autism spectrum disorder,ASD）儿童在心理教育评估量表第3版（PEP-3）中反应特征,为临床诊断和康复提供可循依据。方法以智力测试结果为界定标准,选择低功能ASD（LFA）、高功能ASD（HFA）和正常对照组儿童各26例,各组性别、年龄相匹配各组男23例、女3例,年龄在2-5岁间,平均年龄分别为（40.92±9.60）、（40.07±7.60）、（40.12±9.31）月,采用香港版PEP-3量表的功能发展量表对其进行测评分析。结果 LFA儿童在PEP-3所有功能领域的原积分和发展年龄均明显落后于对照组（P〈0.001）,HFA组的认知、大肌肉测验的原积分和发展年龄均低于对照组（P〈0.05）;LFA组的认知、语言表达、语言理解、模仿测验的原积分和发展年龄均明显低于HFA组（P〈0.001）,小肌肉测验的原积分和发展年龄均低于HFA组（P〈0.05）。LFA组在合成项沟通和体能的功能商数表现为＂低-高＂趋势（51.68±14.34VS 75.08±9.00,P〈0.001）,HFA组则呈现＂均衡＂现象（91.40±12.93VS87.02±11.66,P=0.205）。结论不同认知功能ASD儿童PEP-3评价结果反映了不同模式,可作为辅助诊断和教育干预的参考。Objective To explore the developmental profile of children with autism spectrum disorder （ASD） on PEP- 3. Methods A total of 52 children with ASD who were divided into two groups according their intelligence level,lowfunction autism （LFA） and high-functioning autism （HFA） ,and 26 aged-matched typically children were evaluated by PEP- 3 （each group included 23 boys and 3 girls,aged 2-5 years old）. Results LFA children exhibited a greater developmental delay in all subtests on PEP-3 as compared with typically children （P〈0. 001）. The scores and developmental ages on the cognitive verbal/preverbal （CVP） and gross motor （GM） subtests were lower in HFA group than TD group （P〈0.05）. LFA group significantly scored lower than HFA group on CVP, expressive language （EL）, receptive language （RID, fine motor （FM） and visual motor imitation （VMI） subtests （P〈0.05）. For the communication composite and motor compos ite, children with LFA exhibited ＂low-high＂ trend （51.68 ±14.34 VSs 75.08±9.00, P〈0.001）, while HFA group presented ＂balanced＂ phenomenon （91.40±12.93 VS 87.02±11.66,P=0. 205）. Conclusion Children with ASD of different intelligence level exhibites differently on PEP-3.

关 键 词：孤独症谱系障碍 PEP-3 反应模式 

分 类 号：R749.94[医药卫生—神经病学与精神病学]